Book Description:
This book looks at genotoxicity which is a deleterious action on cell genetic material affecting its integrity. Genotoxic substances are known to be potentially mutagenic or carcinogenic, specifically those capable of causing genetic mutation and of contributing to the development of tumors. In humans, DNA damage or genotoxicity may be caused by exposure to outside agents like radiation, pesticides, combustion of hydrocarbon products as well as antineoplastic drugs. DNA damage could also come from inside of the body, determined mainly by excessive free radical production generated by some disease process. The importance then, is to identify the genotoxity and try to protect the body, which may be as simple as removing the source of exposure or providing protection against such agents. This new important book gathers the latest research from around the globe in this dynamic field of study.

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Table of Contents:
Preface

Chapter I. The Importance of the In Vitro Genotoxicity Evaluation of Food Components: The Selenium;pp. 1-40
(Vanessa Valdiglesias, Josefina Méndez, Eduardo Pásaro, Blanca Laffon, Toxicology Unit, Dept. Psychobiology, University of A Coruña, Edificio de Servicios Centrales de Investigación, Spain, and others)

Chapter II. In Vitro High-throughput Assays for Assessment of Genetic Toxicology;pp. 41-77
(Xuemei Liu, Jeffrey A. Kramer, Larry D. Kier, and Alan G. E. Wilson, Drug Metabolism, Pharmacokinetics, and Toxicology, Lexicon Pharmaceuticals, Inc., The Woodlands, TX, and others)

Chapter III. Genotoxicity Evaluation of Exposure to Lead;pp. 79-109
(Julia García-Lestón, Josefina Méndez, Eduardo Pásaro, Blanca Laffon, Toxicology Unit, Dept. Psychobiology, University of A Coruña, Edificio de Servicios Centrales de Investigación, Spain, and others)

Chapter IV. Genotoxicity by micronucleus assay for medical devices development;pp. 111-126
(Andrea Cecilia Dorion Rodas – Instituto de Pesquisas Energéticas e Nucleares – Biotechnology Centre, Patricia Santos Lopes – Universidade de Sorocaba – Faculty of Pharmacy, Olda Zazuco Higa - Instituto de Pesquisas Energéticas e Nucleares – Biotechonology Centre)

Chapter V. Genotoxicity Produced by Disease and Drugs;pp. 127-156
(Guillermo M. Zúñiga-González, Belinda C. Gómez-Meda, Ana L. Zamora-Perez, Martha P. Gallegos-Arreola, Laboratorio de Mutagénesis, Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, México, and others)

Chapter VI. Modification of Chemical Mutagenesis;pp. 157-187
(A.D. Durnev, A.K. Zhanataev, E.S. Voronina, L.A. Oganesyantz, S.B. Seredenin, State Foundation Institute of Pharmacology of Russian Academy of Medical Sciences, and others)

Chapter VII. Co-Mutagenic Effects of Nifedipine and Diltiazem In Vivo;pp. 189-199
(A.D. Durnev, A.K. Zhanataev, N.O. Daugel'-Dauge, A.V. Kulakova, E.A. Anisina, State Foundation Institute of Pharmacology of Russian Academy of Medical Sciences)

Chapter VIII. Usefulness of Bulky DNA Adduct Formation as a Biological Marker of Exposure to Airborne Particulate Matter (Pm2.5) in In Vitro Cell Lung Models: A Comparative Study;pp. 201-223
(Sylvain Billet, Véronique Andre, Imane Abbas, Jeremie Le Goff , Anthony Verdin, François Sichel, Pirouz Shirali, Guillaume Garçon, Toxicologie Industrielle et Environnementale, Université du Littoral - Côte d’Opale, Maison de la Recherche en Environnement Industriel de Dunkerque, France, and others)

Chapter IX. Impact Assessment and Evaluation of Cadmium-Induced Genotoxicity and Clastogenicity in Mice;pp. 225-251
(Malay Chatterjee and Mary Chatterjee, Chemical Carcinogenesis and Chemoprevention Laboratory, Division of Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, India)

Chapter X. Loss of Heterozygosity and/or Microsatellite Instability in Multiple Critical Regions of 3p and 9p Chromosomes in Human Epithelial Lung Cells (L132) Exposed to Air Pollution Particulate Matter (Pm2.5);pp. 253-274
(Françoise Saint-Georges, Guillaume Garçon, Fabienne Escande, Imane Abbas, Anthony Verdin, Pierre Gosset, Philippe Mulliez, Pirouz Shirali, Service de Pneumologie, Hôpital Saint-Philibert, Groupement Hospitalier de l’Institut Catholique-Faculté Libre de Médecine de Lille, France, and others)

Chapter XI. Prediction of the Human Radiosensitivity: What is the Most Relevant Endpoint? Gene Expressions, Mutations or Functions?;pp. 275-291
(Catherine Massart, Aurélie Joubert, Adeline Granzotto, Muriel Viau,Fawzia Seghier, Jacques Balosso, and Nicolas Foray, European Synchrotron Radiation Facility, France, and others)

Chapter XII. Application of Genotoxicity to Dental Materials Research;pp. 293-309
(Daniel Araki Ribeiro, Department of Biosciences, Federal University of Sao Paulo, Brazil)

Chapter XIII. Use of the Comet Assay to Evaluate Pesticide Toxicity on Non-Target Microalgae;pp. 311-319
(Prado, R., Díaz, R., Rioboo, C., Abalde, J., Herrero, C. & Cid, A., Laboratorio de Microbiología, Facultad de Ciencias, Universidad de A Coruña, Spain)

Commentary

Numberless drugs are not adequately tested for the potential genotoxic-carcinogenic risk to humans;pp.321-329
(Giovanni Brambilla and Antonietta Martelli, Department of Internal Medicine, Division of Clinical Pharmacology and Toxicology, University of Genoa, Genoa, Italy)

Index