Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Ebooks » Biomedical Sciences » Medicine » Cancer » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Central Asia: Perspectives and Present Challenges
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
01.Overcoming the Barriers of the Central Nervous System: Novel Methods of Drug Delivery to Brain Cancer (pp. 1-21)
02.Brain Cancer Therapy and Surgical Interventions (Horizons in Cancer Research, Volume 27)
03.Horizons in Cancer Research. Volume 48
04.Tumor Budding in Colorectal Cancer: Recent Progress in Colorectal Cancer Research (E)
05.Anticancer Drugs: Design, Delivery and Pharmacology
06.Aromatase Inhibitors: Types, Mode of Action and Indications
07.Desmoplastic Small Round Cell Tumor
08.Handbook of Skin Care in Cancer Patients
09.New Insights into Functional Mapping in Cerebral Tumor Surgery
10.Ovarian Cancer: New Research (E)
Notifications more
NotificationsNotify me of updates to New Insights into Functional Mapping in Cerebral Tumor Surgery
Tell A Friend
Tell someone you know about this product.
New Insights into Functional Mapping in Cerebral Tumor Surgery $35.00
Authors: Hugues Duffau (Department of Neurosurgery Hôpital Salpêtrière, Paris, France) 
Book Description:
The rationale of brain tumor surgery depends on two antagonist goals: on one hand, to optimize the quality of resection, on the other hand, to minimize the risk of permanent postoperative deficit. However, due to the physiological interindividual anatomo-functional variability, increased in cases of cerebral tumors because of the plastic potential of the brain, a study of the interactions between the lesion and the host seems mandatory – in order to understand the individual dynamic organization of the brain, then with the goal to avoid postsurgical sequelae.

In this way, new methods of functional brain mapping can be useful for the neurosurgeon.

First, before surgery, non-invasive functional neuroimaging techniques (fMRI, PET, MEG) and invasive extraoperative electrical mapping (subdural grids) may allow to study the cortical organization for each patient. Furthermore, Diffusion Tensor Imaging can help to understand the brain connectivity. Thus, the relationships between the tumor and the eloquent areas can be estimated, and these data applied to the surgical planning.

Second, during surgery, direct intraoperative electrical stimulation permits to detect with accuracy and reliability, both the cortical sites and the white pathways essential for a given function, at each moment and each place of the tumor removal. Moreover, repeated stimulations all along the surgical act also allow to study the mechanisms of short-term plasticity, induced by the resection itself. This on-line mapping is used to tailor the resection according to cortico-subcortical functional boundaries.

Third, postoperative neurofunctional imaging, combined to the precise evaluation of the clinical course and the objective assessment of the location and extent of resection, gives the opportunity to study the mechanisms underlying the functional compensation, i.e. the long-term plasticity. This potential may be used to perform a second surgery with a better quality of resection than the first one, thanks to possible brain remapping.

Such a pre-, intra- and post-surgical longitudinal study of dynamic interactions between brain and lesion, allows to better apprehend the distinct patterns of functional redistribution for each patient, thus to apply this knowledge in order:

• to better select the surgical indication in brain tumors;
• to better inform the patient of the actual risk of transient postoperative deficit;
• to better plan the resection (surgical approach, cortico-subcortical boundaries);
• to optimize the quality of tumor removal while preserving the functional areas and tracts;
• and to plan a specific rehabilitation.

Finally, on a fondamental point of view, the association of methods of functional mapping in neurosurgical patients allows to better understand the pathophysiology of brain areas, their connectivity, and the mechanisms of plastic potential of the glio-neurono-synaptic networks.

Table of Contents:

I - Introduction

II – Study of the Dynamic Biological Behavior of the Tumor

III – Study of the Dynamic Organization of the Brain

IV – Study of the Dynamic Interactions Between the Tumor and the Brain

V – Surgical Results

VI - Conclusions and Perspectives


   Binding: ebook
   Pub. Date: 2008 4th Quarter
   ISBN: 978-1-60741-397-4
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
Available Options:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2021

New Insights into Functional Mapping in Cerebral Tumor Surgery