Book Description:
In consolidation of the most updated experimental results and perspectives from diverse research fields on a main theme - Intermittent Hypoxia, this book encompasses the structural, physiological, pathophysiological, biochemical, genetic, metabolic, and therapeutic aspects of intermittent hypoxia and provides an open forum to promote the bench-to-bed translational implications of both adaptive (beneficial) and maladaptive (detrimental) responses to intermittent hypoxia in animals and humans. Authored by 74 leading scientists from 17 countries in Asia, Europe, North America, and Oceana, the 30 chapters are grouped under 7 different sections covering the profound effects of intermittent hypoxia particularly on cardiovascular, respiratory, nervous, and skeletal muscular systems. Special attentions are paid to the protective or injurious roles played by intermittent hypoxia and their underlying cellular and molecular mechanisms in several major human diseases such as acute myocardial infarction, stroke, sleep apnea, and Parkinson’s disease. Several chapters have also reviewed the use of intermittent hypoxia training for enhancing exercise performance in elite athletes. Overall, as endorsed by Professor John B. West (Member, Institute of Medicine, National Academy of Sciences of U.S.A.; Editor-in-Chief, High Altitude Medicine and Biology) through his Foreword for the book, this is the most comprehensive monograph to date on the topic of intermittent hypoxia, which can cause significant structural and functional impact on the systemic, organic, cellular and molecular processes of human physiology and pathophysiology. Hence, this book could serve as a thorough reference for research scientists, physicians, academic faculty, graduate and medical students, athletic coaches and trainers, who are interested in enhancing their knowledge about the past, present, and future of intermittent hypoxia research and its translational applications for prevention and treatment of major diseases and improving exercise performance.

Table of Contents:
Preface
Lei Xi and Tatiana V. Serebrovskaya

Foreword (John B. West)

Historical Overview of Intermittent Hypoxia Research
(Tatiana V. Serebrovskaya and Lei Xi)

Section 1. Intermittent Hypoxia and Cardiovascular System pp.1-2

Chapter 1. Contrasting Effects of Intermittent Hypoxia on Myocardial Ischemic Tolerance
(Elise Belaidi, Amandine Ramond, Marie Joyeux-Faure, Patrick Levy, Christophe Ribuot and Diane Godin-Ribuot)pp.3-18

Chapter 2. Effects of Intermittent versus Chronic Hypoxia on Myocardial Ischemic Tolerance
(Michele Samaja, Arsenio Veicsteinas and Giuseppina Milano) pp.19-52

Chapter 3. Intermittent Hypoxia-Induced Cardioprotection via iNOS-Dependent Signaling Mechanism
(Lei Xi and Demet Tekin)pp.53-78

Chapter 4. Intermittent Hypoxia-Induced Cardio- and Vasoprotection: Role of NO Stores
(Eugenia B. Manukhina, Anatoly F. Vanin, Igor Yu. Malyshev, Robert T. Mallet, and H. Fred Downey)pp.79-112

Chapter 5. Intermittent Hypoxia in Resistance of Cardiac Membrane Structures: Role of Reactive Oxygen Species and Redox Signaling
(Tatyana G. Sazontova and Yuriy V. Arkhipenko)pp.113-150

Chapter 6. Beta-Adrenergic Signaling and ROS: Pivotal Roles in Intermittent, Normobaric Hypoxia-Induced Cardioprotection
(Robert T. Mallet, Myoung-Gwi Ryou, Eugenia B. Manukhina, and H. Fred Downey)pp.151-174

Chapter 7. Role of Protein Kinases in Chronic Intermittent Hypoxia-Induced Cardioprotection
(Frantisek Kolar, Frantisek Novak, Jan Neckar, Olga Novakova, Marketa Hlavackova, Bohuslav Ostadal, and Rene J.P. Musters)pp.175-192

Chapter 8. Effects of Intermittent Hypoxia on VEGF Expression and Angiogenesis in Cardiac and Skeletal Muscles
(Demet Tekin and Lei Xi)pp.193-210

Chapter 9. Effects of Sleep-Disordered Breathing on Autonomic
Cardiovascular Control: A Bioengineering Perspective
(Michael C.K. Khoo)pp.211-232

(Chapter 10. Effects of Intermittent Hypoxia on Pulmonary Arterial Pressure and Right Ventricular Mass
(Aidan Bradford and Ken D. O’Halloran)pp.233-242

Section 2. Intermittent Hypoxia and Respiratory System

Chapter 11. Effects of Intermittent Hypoxia on Ventilatory Response
(Keisho Katayama)pp.245-260

Chapter 12. Intermittent Hypercapnia
Mieczyslaw Pokorski and Tatiana V. Serebrovskaya pp.261-274

Chapter 13. Upper Airway Dysfunction Following Chronic Intermittent Hypoxia – Implications for Sleep-Disordered Breathing
(Ken D. O’Halloran)pp.275-292

Chapter 14. Effects of Intermittent Hypoxia on Pulmonary Haemodynamics
(Jan Zielinski and Robert Pływaczewski)pp.293-310

Section 3. Intermittent Hypoxia and Nervous System

Chapter 15. Hypoxic Preconditioning Protects Against Oxidative Injury in the Central Nervous System
Anya M.Y. Lin pp.313-328
Chapter 16 Effects of Intermittent Hypoxia on Neurogenesis in the Adult and Parkinsonian Rat
(Ling-ling Zhu, Xuan Wang, Xiao-Ming Wang, and Ming Fan)pp.329-344

Chapter 17. Neurotransmitter Synthesis during Intermittent Hypoxia: Role of ROS-Dependent Post-Translational Protein Modifications
(Ganesh K. Kumar and Nanduri R. Prabhakar)pp.345-356

Section 4. Genetic and Molecular Aspects of Intermittent Hypoxia

Chapter 18. The Role of HIF-1 and ROS in Cellular and Systemic Responses to Intermittent Hypoxia
(Nanduri R. Prabhakar and Gregg L. Semenza)pp.357-370

Chapter 19. Genetic Selection for Tolerance and Adaptation to Hypoxia
(Tsering Stobdan, Jayashree Karar, and MA Qadar Pasha pp.371-390

Chapter 20. Mitochondrial Signaling in Formation of Body Resistance to Hypoxia
(Ludmila D. Lukyanova, Alexandr V. Dudchenko, Elita L. Germanova, Tatyana A. Tsybina, Revas A. Kapaladze, Igor V. Ehrenbourg, and Elena .N. Tkatchouk)pp.391-418

Chapter 21. HIF1α, HIF2α, HIF3α and HIF1β mRNA Expression Changes in Different Tissues under Intermittent Hypoxic Training
(Tetyana Drevitska, Victor Dosenko, Vasiliy Nagibin and Iryna Mankovska)pp.419-436

Chapter 22. Hypoxia and Stem Cells
(Igor Nikolsky and Tatiana V. Serebrovskaya)pp.437-456

Section 5. Intermittent Hypoxia and Sports Training

Chapter 23. Effects of Intermittent Hypoxia Training on Peak Performance in Elite Athletes
(Gregoire P. Millet, Xavier Woorons, and Belle Roels) pp.459-472

Chapter 24. Use of Intermittent Hypoxia Training in Different Sports
(Pavel Radzievski and Maria Radzievska)pp.473-486

Chapter 25. Effects of Intermittent Hypoxia Training on Cytokine Responses to Exercise
(Jong-Shyan Wang)pp.487-502

Chapter 26. Intermittent Hypoxia Exposure and Sleep in Athletes
(Chin Moi Chow, Daniel Davies, and Tahnee Kinsman)pp.503-518

Chapter 27. Effects of Intermittent Hypoxia on Oxygen-Dependent Processes in Skeletal Muscles under Endurance Training
(Iryna Mankovska, Bronislav Gavenauskas, Valentyna Nosar, Olga Gonchar, Larisa Bratus, and Natalia Kurhalyuk)pp.519-536

Section 6. Clinical and Therapeutic Aspects of Intermittent Hypoxia

Chapter 28. Use of Intermittent Normobaric Hypoxia Trainings in Elderly People
(Oleg V. Korkushko, Valery B. Shatilo, V.A. Ishchuk, and Maya I. Tourta)pp.537-548

Chapter 29. Parkinson’s Disease and Intermittent Hypoxia Training
(Evgenia E. Kolesnikova and Tatiana V. Serebrovskaya)pp.549-560

Chapter 30. Equipment and Regimes for Intermittent Hypoxia Therapy
(Oleg Bassovitch and Tatiana V. Serebrovskaya)pp.561-572

CONTRIBUTOR LIST pp.573-578

Index pp.579-615