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Telomerase: Composition, Functions and Clinical Implications
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Editors: Aiden N. Gagnon
Book Description:
Telomerase is a ribonucleoprotein enzyme that catalyzes the cellular synthesis of telomeric DNA during cellular division, resulting in maintenance of telomere length and increased proliferative potential.
Several studies suggest that the telomerase may play an important role in the diagnosis and prognosis of cancer because its expression strongly correlates with the potential tumor progression. Ninety percent of human cancers on different organs have shown high telomerasa activity. This book reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others.


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Please click on a chapter below to purchase separately

Chapter 1 - Telomerase beyond Telomeres: New Roles for an Old Enzyme pp. 1-34
Authors / Editors: (Gabriele Saretzki, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne NE1, United Kingdom)
***Open Access Chapter. Free Download Available***

Chapter 2 - Telomerase and Telomeric Proteins: A Life Beyond Telomeres pp. 35-58
Authors / Editors: (Ilaria Chiodi, Cristina Belgiovine, Chiara Mondello, Istituto di Genetica Molecolare, CNR, Pavia, Italy)
***Open Access Chapter. Free Download Available***

Chapter 3 - Histone Deacetylase Inhibition as an Anticancer Telomerase-Targeting Strategy pp. 59-79
Authors / Editors: (Ruman Rahman, Children’s Brain Tumour Research Centre, Medical School, University of Nottingham, United Kingdom)

Chapter 4 - Telomerase Role in Pituitary Adenomas pp. 81-94
Authors / Editors: (A. Ortiz-Plata, Laboratory of Experimental Neuropathology, National Institute of Neurology and Neurosurgery, Mexico City, Mexico)
***Open Access Chapter. Free Download Available***

Chapter 5 - Regulations of Telomerase Activity and WRN Gene Expression pp. 95-103
Authors / Editors: (Fumiaki Uchiumi, Yoshikazu Higami, Sei-ichi Tanuma, Tokyo University of Science, Chiba, Japan
***Open Access Chapter. Free Download Available***

Chapter 6 - Telomerase and Telomere Dynamics in Cancer: Clinical Application for Cancer Diagnosis pp. 105-144
Authors / Editors: (Eiso Hiyama, Keiko Hiyama, Natural Science Center for Basic Research and Development, Hiroshima University, Hiroshima, Japan, and others)

   Series:
      DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
   Binding: Hardcover
   Pub. Date: 2010
   Pages: 6 x 9
   ISBN: 978-1-61668-957-5
   Status: AV
  
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
  
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Telomerase: Composition, Functions and Clinical Implications