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Glucocorticoids: Effects, Action Mechanisms, and Therapeutic Uses
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Editors: Annemarie C. Pelt
Book Description:
Glucocorticoids (GC) are a class of steroid hormones that bind to the glucocorticoid receptor, which is present in almost every vertebrate animal cell. GCs are part of the feedback mechanism in the immune system that turns immune activity (inflammation) down. They are therefore used in medicine to treat diseases that are caused by an overactive immune system, such as allergies, asthma, and autoimmune diseases. GCs have many diverse effects, including potentially harmful side effects, and as a result are rarely sold over-the-counter. This book presents topical research from around the globe in the study of glucocorticoids, including the role of genetics in predicting glucocorticoid clinical response; the glucocorticoid receptor signaling in cancer and inflammation; the mechanisms of NO-redox imbalance in glucorticoid hypertension; and GCs in perioperative care.

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Chapter 1 - Pharmacogenetics of Glucocorticoid Response pp. 1-33
Authors / Editors: Raffaella Franca, Sara De Iudicibus, Giuliana Decorti, Institute for Maternal and Child Health IRCCS Burlo Garofolo, Trieste, University of Trieste, Trieste, Italy, and others

Chapter 2 - The Glucocorticoid Receptor Signaling in Cancer and Inflammation pp. 35-60
Authors / Editors: E. Kassi, P. Moutsatsou, Laboratory of Clinical Biochemistry, Attikon University Hospital, Haidari, Athens, Greece, and others

Chapter 3 - Glucocorticoids – Age Specific Impact on Mitochondrial Energy Homeostasis pp. 61-85
Authors / Editors: Jignesh D. Pandya, Surendra S. Katyare, Research Scientist, Spinal Cord & Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, Kentucky, USA, and others

Chapter 4 - Glucocorticoids, Stress and Cancer: New Insights in Immune System and Tumour Cell Regulations pp. 87-106
Authors / Editors: Luciana Romina Frick, Maximilano Rapanelli, Graciela Alicia Cremaschi, Ana María Genaro, Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Primera Cátedra de Farmacología, Universidad de Buenos Aires, Argentina, and others

Chapter 5 - Hypothalamic Obesity: A Pivotal Role of Endogenous Glucocorticoid pp. 107-128
Authors / Editors: Eduardo Spinedi, Andres Giovambattista, Rolf C. Gaillard, Neuroendocrine Unit, Multidisciplinary Institute on Cell Biology (IMBICE, CONICET-CICPBA), La Plata, Argentina, and others

Chapter 6 - The Role of Nitric Oxide: Redox Imbalance in Glucocorticoid-Induced Hypertension pp. 129-146
Authors / Editors: Yi Zhang, Judith A. Whitworth, Cardiovascular Research, The Canberra Hospital, Canberra, Australia, and others

Chapter 7 - Glucocorticoids Mediate Drug Resistance: Mechanisms and Its Clinical Impact pp. 147-167
Authors / Editors: Weimin Fan, Meihua Sui, Program of Innovative Cancer Therapeutics, First Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, China, and others

Chapter 8 - Glucocorticoids in Perioperative Care pp. 169-186
Authors / Editors: Arman Kahokehr, Sanket Srinivasa, Tzu Chieh Yu, Tarik Sammour, Andrew G. Hill, Department of Surgery, University of Auckland, Middlemore Hospital, Otahuhu, Auckland, New Zealand

Chapter 9 - Glucocorticoid-Mediated Regulation of Tight Junctions in Brain Vascular Endothelium pp. 187-202
Authors / Editors: Malgorzata Burek, Carola Y. Förster, University Hospital Würzburg, Department of Anaesthesia and Critical Care, Würzburg, Germany
***Open Access Chapter. Free Download Available***

Chapter 10 - Glucocorticoid Therapy for Cochlear Injuries: Pharmacology and Evidence from Animal Experiments pp. 203-216
Authors / Editors: Keiji Tabuchi, Keiko Oikawa, Bungo Nishimura, Yuki Hirose, Shuho Tanaka, Akira Hara, Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan

Chapter 11 - Expert Commentary: Glucocorticoids and Exercise Performance in Humans: Current Status pp. 217-220
Authors / Editors: K. Collomp, J. De Ceaurriz, Laboratoire AMAPP, Université d’Orléans, Orléans, France, and others

Chapter 12 - Glucocorticoids, Thymus Function and Sex Hormone in Human Body Growing pp. 221-244
Authors / Editors: Gordana Bjelakovic, Ivana Stojanovic, Tatjana Jevtovic-Stoimenov, Bojko Bjelakovic, Institute of Biochemistry, University of Nis, Serbia

      Biochemistry Research Trends
   Binding: Hardcover
   Pub. Date: 2011
   Pages: 7 x 10
   ISBN: 978-1-61728-758-9
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Glucocorticoids: Effects, Action Mechanisms, and Therapeutic Uses