Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Medicine » Disorders of Muscles, Bursas and Tendons » Handbook of Spinal Cord Injuries: Types, Treatments and Prognosis Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Brain, Body, Cognition - A continuation of Functional Neurology, Rehabilitation and Ergonomics
$325.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Adult Bone Marrow Stem Cells and Biocompatible Polymers in SCI Repair, pp. 297-320
Tell A Friend
 
Tell someone you know about this product.
Adult Bone Marrow Stem Cells and Biocompatible Polymers in SCI Repair, pp. 297-320 $100.00
Authors:  A. Hejčl, P. JendelovŠ and E. SykovŠ
Abstract:
Spinal cord injury (SCI) is a complex and dynamic process that will require multiple
approaches to yield successful therapy. Bone marrow stem cells and biomaterials
represent an important part of SCI neurotransplantation research in the last decade. The
behavior of rat and human mesenchymal stem cells (MSCs) grafted to the injured spinal
cord has been studied in terms of the cellsí participation in lesion repair, their
differentiation and their ability to promote functional recovery. The fate of MSCs has
been followed using cells labeled in culture with superparamagnetic iron-oxide
nanoparticles. The effects of implanted rat MSCs was compared with the implantation of
a freshly prepared mononuclear fraction of bone marrow cells (BMCs) or the injection of
granulocyte colony-stimulating factor. Lesioned animals grafted with MSCs, BMCs or
treated with G-CSF had significantly smaller lesions and better motor performance. The
transplantation of MSCs in animal models of chronic SCI (which result in cavity
formation) led to only modest improvement. Autologous BMC implantation was used in
a Phase I/II clinical trial in patients with SCI. Intra-arterial vs. intravenous administration
and groups of acute vs. chronic patients were compared. Implantation was safe; in
addition, 5 out of 6 patients with a subacute cervical lesion improved their function
following the administration of BMCs via a. vertebralis.
Various biomaterials, such as hydrogels and nanofibers, have been used to bridge
large pseudocystic cavities. Scaffolds may bridge the gap left after a population of cells
is lost and may also serve as carriers for stem cells, thus supporting tissue reconstruction. Hydrogels and nanofibers based on copolymers of 2-hydroxypropylmethacrylamide and
2-hydroxyethylmethacrylate were implanted in animals with SCI to provide a bridge
across the pseudocystic cavity and to serve as a scaffold for tissue regeneration. Various
physical and chemical modifications of these scaffolds, which were evaluated in vivo, are
discussed. Both therapeutic modalities, i.e. MSCs and hydrogels, can be applied together
to combine the advantages of both therapeutic approaches. Hydrogels were used as 3D
carriers for stem cells and implanted into acute spinal cord lesions. Various hydrogels are
suitable as carriers of MSCs and/or other stem cells, as the cells survived in the hydrogels
for several months. Further, these hydrogel constructs (hydrogel+MSCs) were also tested
in an animal model of chronic SCI. The hydrogel constructs seeded with MSCs created a
successful bridge, preventing tissue atrophy and improving functional outcome. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Adult Bone Marrow Stem Cells and Biocompatible Polymers in SCI Repair, pp. 297-320