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Spinal Cord Ischemia-Reperfusion Injury, pp. 665-679 $100.00
Authors:  A.Tulga Ulus and Sadi Kaplan
Abstract:
Aortic aneurysms and dissections are two of the most insidious disease and
associated with paraplegia in humans. Different strategies of both surgical and nonsurgical
have been developed to reduced the incidence of neurological complications.
Experimental and clinical research have increased our understanding of spinal cord
ischemia-reperfusion injury and encouraged us for the development of a multimodality
approach during aortic surgery.
Inorder to solve the puzzle of pathophysiology of spinal cord ischemia-reperfusion,
reliable and reproducible experimental and clinical monitoring techniques are needed.
We began by producing appropriate experimental models for the spinal cord ischemiareperfusion
injury and than made several experiments inorder to understand and respond
some of the problems.
This review serves to summarise the experimental research which guides our clinical
applications related with the spinal cord ischemia-reperfusion injury. The experimental
models, hemodynamics, biomarkers, cerebrospinal fluid gas changes, pharmacological
therapies and effects of two different periods seperated as ischemia and reperfusion will
be discussed.
Aortic aneurysms and dissections are the two harmful and dreadful diseases in
humans. Thoracoabdominal aortic aneuryms are constitute approximately 5 % of all
aortic aneurysms. The thoracoabdominal aortic aneuryms and dissections have a
incidence of 5-6/100.000 and 10/100.000 (1,2). The surgical therapy for disease presents
many dramatic consequences with serious rate of mortality and morbidity. The surgery
involves the permenant and temporary interruption of blood suply to visceral organs 


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Spinal Cord Ischemia-Reperfusion Injury, pp. 665-679