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NotificationsNotify me of updates to CELLULAR UPTAKE MECHANISM OF INORGANIC NANOVEHICLES FOR DRUG DELIVERY: STRUCTURAL FEATURES AND ENDOCYTIC PATHWAY pp. 115-139
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CELLULAR UPTAKE MECHANISM OF INORGANIC NANOVEHICLES FOR DRUG DELIVERY: STRUCTURAL FEATURES AND ENDOCYTIC PATHWAY pp. 115-139 $100.00
Authors:  Jin-Ho Choy, Soo-Jin Choi, Jae-Min Oh, Center for Intelligent NanoBio Materials, Division of Nano Science, Department of Bioinspired Science and Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea, and others
Abstract:
In this review, the cellular uptake mechanism of inorganic nanoparticles, as drug delivery carrier, is discussed, particularly focusing on layered double hydroxide (LDH). The LDH nanoparticles are biocompatible in general consisting of positively charged metal hydroxide sheets and charge-compensating interlayer anions, which are solvated with water or solvent molecules depending upon synthetic conditions. Such inorganic nanoparticles have attracted a great deal of attention nowadays as nanovehicles due to their efficient delivery behaviors for drugs or genes into cells. Specific internalization pathway, cellular uptake rate, and delivery efficiency of LDHs will be described in details with respect to their structural features such as particle size (50, 100, 200 and 350 nm) and surface modification (folate conjugates). Cellular entry of other inorganic nanoparticles including carbon nanotube, iron oxide and silica will be also discussed with LDHs comparatively. And finally attempts will be made to understand the interaction mechanism between delivery nanovehicles and cells, because it will provide a new perspective for the design of drug delivery nanovehicles with maximized and targeted delivery ability. 


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CELLULAR UPTAKE MECHANISM OF INORGANIC NANOVEHICLES FOR DRUG DELIVERY: STRUCTURAL FEATURES AND ENDOCYTIC PATHWAY pp. 115-139