Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Education » Book Chapters » Trends in Obesity » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Central Asia: Perspectives and Present Challenges
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
01.Recent Advances In The Understanding And Treatment Of Hypothalamic Obesity In Humans (pp. 41-66)
02.Cutaneous Manifestations In Obese Patients (pp. 121-139)
Notifications more
NotificationsNotify me of updates to Gene Expression Pattern Of Obese And Control Individuals In Adipose Tissue And Peripheral Blood Mononuclear Cells (pp. 67-84)
Tell A Friend
Tell someone you know about this product.
Gene Expression Pattern Of Obese And Control Individuals In Adipose Tissue And Peripheral Blood Mononuclear Cells (pp. 67-84) $25.00
Authors:  García-Amigot2, F.; Lamas, O.; Marti, A.; Moreno Aliaga, M. J.; Bandrés, E.; García-Foncillas, J.; Martínez, J. A. (University of Navarra)
Obesity is a serious and growing public health problem throughout the world. Increased food intake and decreased energy expenditure due to sedentary lifestyles in modern societies have contributed to the widespread development of obesity. Moreover, the genetic background is a key factor for different diseases such as diabetes mellitus, hypertension, cancer, obesity, etc. In this context, different genes are involved in the body weight and fat mass maintenance, through their role in the control of afferent mechanisms (leptin, nutrients, nervous signals…), central mechanisms (hypothalamic neurotransmisors) and efferent mechanisms (insulin, catecholamines…). So, energy balance and body composition seems to depend up to a 40% of the genetic background. Several investigations using different approaches and protocols have identified more than 430 genes and genetic markers involved in the onset and development of obesity. In this context, we analysed by a microarray technology the gene expression pattern of obese and control individuals in adipose tissue and peripheral blood mononuclear cells (PBMCs). This approach found 129 genes up-regulated and 1009 genes down-regulated in adipose tissue from control subjects when compared to obese individuals and 15 genes up-regulated and 201 genes down-regulated in lymphocytes of controls compared to obese individuals. These results have been confirmed by real time PCRs on three selected genes (cab45, adra1a, mgc4365). Finally, the data obtained from adipose tissue and PBMCs were conjointly assessed and 35 genes down-regulated both in adipose tissue and lymphocytes from controls compared to obese were found. However, when the profiles of gene expression by quantitative PCRs in adipose tissue and lymphocytes were analysed, only the adipose tissue pattern of gene expression correlated well concerning the microarray validation. Moreover, there was no association in the pattern of gene expression in lymphocytes between the data obtained by microarray and by quantitative PCRs. Summing up, it has been shown that obesity not only affects the pattern of gene expression in adipose tissue, but also the pattern of gene expression in immune system cells, although these patterns do not correlate apparently much between them.
Key Words: Obesity, Lymphocytes, DNA microarrays, real-time PCR. 

Available Options:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Gene Expression Pattern Of Obese And Control Individuals In Adipose Tissue And Peripheral Blood Mononuclear Cells (pp. 67-84)