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01.Recent Advances In The Understanding And Treatment Of Hypothalamic Obesity In Humans (pp. 41-66)
02.Cutaneous Manifestations In Obese Patients (pp. 121-139)
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Gene Expression Pattern Of Obese And Control Individuals In Adipose Tissue And Peripheral Blood Mononuclear Cells (pp. 67-84) $25.00
Authors:  García-Amigot2, F.; Lamas, O.; Marti, A.; Moreno Aliaga, M. J.; Bandrés, E.; García-Foncillas, J.; Martínez, J. A. (University of Navarra)
Abstract:
Obesity is a serious and growing public health problem throughout the world. Increased food intake and decreased energy expenditure due to sedentary lifestyles in modern societies have contributed to the widespread development of obesity. Moreover, the genetic background is a key factor for different diseases such as diabetes mellitus, hypertension, cancer, obesity, etc. In this context, different genes are involved in the body weight and fat mass maintenance, through their role in the control of afferent mechanisms (leptin, nutrients, nervous signals…), central mechanisms (hypothalamic neurotransmisors) and efferent mechanisms (insulin, catecholamines…). So, energy balance and body composition seems to depend up to a 40% of the genetic background. Several investigations using different approaches and protocols have identified more than 430 genes and genetic markers involved in the onset and development of obesity. In this context, we analysed by a microarray technology the gene expression pattern of obese and control individuals in adipose tissue and peripheral blood mononuclear cells (PBMCs). This approach found 129 genes up-regulated and 1009 genes down-regulated in adipose tissue from control subjects when compared to obese individuals and 15 genes up-regulated and 201 genes down-regulated in lymphocytes of controls compared to obese individuals. These results have been confirmed by real time PCRs on three selected genes (cab45, adra1a, mgc4365). Finally, the data obtained from adipose tissue and PBMCs were conjointly assessed and 35 genes down-regulated both in adipose tissue and lymphocytes from controls compared to obese were found. However, when the profiles of gene expression by quantitative PCRs in adipose tissue and lymphocytes were analysed, only the adipose tissue pattern of gene expression correlated well concerning the microarray validation. Moreover, there was no association in the pattern of gene expression in lymphocytes between the data obtained by microarray and by quantitative PCRs. Summing up, it has been shown that obesity not only affects the pattern of gene expression in adipose tissue, but also the pattern of gene expression in immune system cells, although these patterns do not correlate apparently much between them.
Key Words: Obesity, Lymphocytes, DNA microarrays, real-time PCR. 


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Gene Expression Pattern Of Obese And Control Individuals In Adipose Tissue And Peripheral Blood Mononuclear Cells (pp. 67-84)