The Biopsychology Of Appetite Regulation: Implications For The Treatment Of Obesity (pp. 157-177)
Authors: Halford, Jason C. G. (University of Liverpool)
Abstract: The expression of appetite is underpinned by a complex set of peripherally generated signals. Some signals are episodic, produced by the anticipation, consumption, digestion and absorption of specific meals. Such factors underpin the flux in appetite, experience as hunger and satiety, we experience across the day. Key hormonal satiety factors include CCK, PYY3- 36, Amylin and GLP-1. Other, signals are tonic, produced by the storage and metabolism of energy within the body. Such signals (for example leptin and adiponectin) moderate the drive to consume potently influencing feeding behaviour as well as energy expenditure. Both episodic and tonic signals influence the actively of anabolic and catabolic circuits that project into the hypothalamus. Within this neural circuitry numerous neuropeptides, both orexogenic (NPY, MCH, Orexin-A, Galanin) and anorexogenic (POMC, CART, CRH), have been identified which stimulate and inhibit food intake. All these systems appear critical in controlling energy balance and thus provide useful therapeutic targets for the treatment of obesity.