Interaction between cognition and mood regulation is a common neural and behavioral phenomenon. This book brings together an international group of neuroscientists who are investigating neural and molecular mechanisms underlying cognition, mood, and interactions between cognition and mood. Exciting advances are occurring in the understanding of the neural and molecular link between dementia and depression. This unique book provides a comprehensive overview of cognitive and mood neurosciences, with a strong emphasis on interactions between dementia and depression. It begins with an introduction to the fundamental concepts of dementia and depression and core issues facing clinical and neurological investigators. Then, several chapters cover the neurochemical substrates underlying the manifestation of cognition and mood regulation, including monoamines, excitatory amino acids, and angiotensins. Separate chapters are devoted to animal models of human dementia and behavioral changes in Alzheimer’s dementia, the most common cause of progressive decline of cognition in aged humans. Subsequent chapters cover common molecular and neural abnormalities of cognitive impairments and mood deregulation, including topics such as neural atrophy, cholesterol, stress, and aging. The book ends with current knowledge of convergence of antidementic and antidepressive pharmacology.
The book is intended for scientists involved in the field, who may want a broader knowledge of all the aspects related to cognition and mood regulation, and for PhD or MD students, residents and neurologists who may wish to learn more about the interactions between cognition and mood. Neuropharmacologists will also benefit from the knowledge presented in the book in developing drugs that are more efficient to modify cognition and mood and more effective to restore normal cognitive and mood regulation.