How Chemokines Implicate in T Lymphocyte Biology pp. 47-72
Authors: Carmen Penido, Maria Fernanda de Souza Costa, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
Abstract: Within the broad spectrum of activities of the small polypeptides called chemokines, there is the modulation of T lymphocytes, which is exerted by members of the four chemokine subfamilies. From the start, chemokines mediate progenitor T cell migration from the bone marrow into the thymus. Thereafter, they coordinate T lymphocytes‘ emigration from the thymus, tissue-specific homing, recirculation and effector functions during host defense. The expression pattern of chemokine receptors also helps to determine functionally distinct T lymphocyte subsets and to phenotype central and effector memory T lymphocytes. T lymphocytes also produce a wide range of chemokines, which have shown to have crucial impact on important features of the inflammatory response triggered by pathogens or allergens. This review addresses the current knowledge of chemokines on development, migration, phenotyping and functions of T lymphocyte during homeostatic and inflammatory conditions, highlighting the importance of chemokines on T lymphocyte biology.
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