Role of CXC-Chemokines CXC-Receptors in Metastasis of Colorectal Cancer pp. 137-154
Authors: Kathrin Rupertus, Otto Kollmar, Michael D. Menger, Martin K. Schilling, Department of General, Visceral, Vascular and Pediatric Surgery, University of Saarland, Homburg, Saar, Germany, and others
Abstract: Chemotactic cytokines (chemokines) are inflammatory cytokines that stimulate the migration of distinct subsets of cells, including leukocytes, lymphocytes and tumor cells. The chemokines MIP (macrophage inflammatory protein)-2 and SDF (stromal cell-derived factor)-1, which are both members of the CXC-chemokine superfamily, are supposed to have an important impact on tumor progression and metastasis. In our recent studies we investigated the chemotactic response of CT26.WT colorectal cancer cells on MIP-2 and SDF-1 in vitro and the influence of these chemokines on tumor growth in vivo.