Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Medicine » Medical General » Advances in Medicine and Biology. Volume 13, Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to The Novel Role of Cell Cycle Checkpoint Clamp Rad9-Hus1-Rad1 (the 9-1-1 complex) in DNA repair pp. 41-74
Tell A Friend
Tell someone you know about this product.
The Novel Role of Cell Cycle Checkpoint Clamp Rad9-Hus1-Rad1 (the 9-1-1 complex) in DNA repair pp. 41-74 $0.00
Authors:  (Amrita Madabushi and A-Lien Lu)
Genotoxic stress damages DNA and exerts deleterious effect on cells resulting in genetic instability. DNA repair pathways are critical components of the cellular defense against cancer and aging. Eukaryotes have evolved complex regulatory mechanisms that coordinate DNA repair with DNA replication, cell cycle regulation, and transcription. Following DNA damage, the cell cycle checkpoints induce signal transduction cascades which arrest cell cycle progression, enhance DNA repair, and can stimulate apoptosis. The heterotrimeric sliding clamp Rad9-Rad1-Hus1 (the 9-1-1 complex) acts as a cell cycle checkpoint sensor and is loaded onto DNA by Rad17-RFC clap loader. Besides serving as damage sensor, recent findings indicate that the 9-1-1 complex is a component of base excision (BER), mismatch repair (MMR), and nucleotide excision repair (NER) pathways.
The 9-1-1 complex interacts with and stimulates several DNA glycosylases, the first enzyme of the BER cascade, including MutY homolog (MYH), 8-oxoG glycosylase (OGG1), Nei-like protein (NEIL1), thymineDNA glycosylase (TDG), and methyl-binding domain IV (MBD4).MYH, OGG1, and NEIL1 are involved in the repair of oxidized bases while TDG and MBD4 are responsible for removing thymine and uracil in T/G and U/G mispairs arisen through deamination. The 9-1-1 complex also interacts with and stimulates other components of BER including DNA polymerase (POLβ), apurinic/apyrimidinic endonuclease 1 (APE1), flap endonuclease 1 (FEN1), replication protein A (RPA), and DNA ligase l (LIG1). Thus, the 9-1-1 complex serves as a BER component and may provide a platform to coordinate the BER process. 

Available Options:

  Open Access item.
  Click below PDF icon for free download.


This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

The Novel Role of Cell Cycle Checkpoint Clamp Rad9-Hus1-Rad1 (the 9-1-1 complex) in DNA repair pp. 41-74