Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Medicine » Medical General » Advances in Medicine and Biology. Volume 13, Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects
$73.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Nitrotyrosine as a Biomarker of Diabetes pp. 177-203
Tell A Friend
 
Tell someone you know about this product.
Nitrotyrosine as a Biomarker of Diabetes pp. 177-203 $100.00
Authors:  (Magdalena Stobiecka and Maria Hepel, Department of Chemistry, State University of New York at Potsdam, Potsdam, NY, 13676, U.S.A)
Abstract:
Recent advances in genetics, genomics, and proteomics offer a great opportunity for the identification of new biomarkers for diabetes.The newly discovered biomarkers have the potential to provide an increased accuracy in the diagnosisand classification of diabetes and, more importantly, to provide means for monitoring of the disease development and controlling the drug delivery in the applied therapeutic intervention. Accurate prediction and identification of diabetes using biomarkers is a key factor for disease prevention so that therapy can be provided to those individuals who are most likely to develop the disease or in early stages of the disease. There is now mounting evidence that oxidative and nitrosative stress resulting from hyperglycemia is involved in the development of diabetes and is implicated in the micro- and macrovascular complications of the disease.Different mechanisms involved in the pathogenesis of complications related to diabetes result from a single hyperglycemia-induced process of the overproduction of superoxide by the mitochondrial electron-transport chain. Such biomarkers of oxidative stress as nitrotyrosine and homocysteine show elevated levels and glutathione shows a decreased level in a progressing disease. In this study, the interactions of nitrotyrosine with gold nanoparticles and two fluorescent dyes with different spectral characteristics have been investigated. These interactions result in changes in the resonance elastic light scattering (RELS) and fluorescence quenching that can be utilized in designing assays for the biomarker. In contrast to homocysteine and glutathione that induce gold nanoparticle assembly in specific pH ranges, no aggregation of nanoparticles has been found in the presence of nitrotyrosine. The adsorptionmeasurements of nitrotyrosine and coumarin C120 on a QC/Au piezoelectrode corroboratethe observed RELS and static fluorescence quenching effects. 


Available Options:
Version:
This Item Is Currently Unavailable.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Nitrotyrosine as a Biomarker of Diabetes pp. 177-203