Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Medicine » Medical General » Advances in Medicine and Biology. Volume 13, Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Theory of Literature
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to ATP-Dependent Stabilization of Fibroblast Growth Factor 2: A New Function of Extracellular ATP?
Tell A Friend
Tell someone you know about this product.
ATP-Dependent Stabilization of Fibroblast Growth Factor 2: A New Function of Extracellular ATP? $100.00
Authors:  (Karsten Rose, Department of Pharmaceutical and Medicinal Chemistry, University of Münster, Münster, Germany)
The discovery of the adenosinetriphosphate (ATP)-molecule by Karl Lohmannn in 1929 paved the way for an in-depth understanding that ATP is the universal form of direct energy in the cell. The hydrolysis of one or two acid anhydride bonds between the phosphate groups provides 32.3 kJ/mol and 64.6 kJ/mol energy, respectively. For some decades an additional role of ATP apart from the function as energy source and the role as a phosphate donor of kinase reactions was unthinkable.
In 1970, Geoffrey Burnstock postulated that ATP could function also as an extracellular signal in nerve-mediated response of muscle cells. First, his investigations were ridiculed and negated, today purinergic receptor signaling is one of the most competitive and important aspect in the field of signal transduction.
Recently, another function of ATP has been postulated: extracellular stabilization of the fibroblast growth factor 2, FGF2 (Rose et al., 2010). FGF2 plays a pivotal role in many biological processes like cell proliferation, embryogenesis, wound healing and angiogenesis (Ornitz and Itoh, 2001). The proliferative effect of FGF2 on endothelial cells leads to the pro-angiogenic phenotype of this growth factor.One interesting feature of this growth factor is its short half-life period. The half-life period in aqueous solution ranges from a few minutes to a few hours (Caldwell et al., 2004). This relative instability of FGF2 could be compensated by binding to heparin or heparansulphate proteoglycanes (HSPGs), which can protect the growth factor from proteolytic digestion and thermal destabilisation (Sommer and Rifkin, 1989). Beside heparin and HSPGs some other stabilizers of FGF2 were identified, though most of them neither occurred nor possessed a physiological function in human cells or tissues (Kajio et al., 1992; Mi et al., 2006; Ni et al., 2007). 

Available Options:
This Item Is Currently Unavailable.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

ATP-Dependent Stabilization of Fibroblast Growth Factor 2: A New Function of Extracellular ATP?