The Impact of Vitamin K-Dependent Proteins on Vascular Calcification in Patients with Kidney Disease pp. 207-216
Authors: (Arjuna Ponnampalam, Manish M. Sood, Department of Medicine, Section of Hematology, University of Manitoba, Winnipeg, Manitoba, Canada, and others)
Abstract: Vascular calcification is accelerated in patients with chronic kidney disease (CKD) due to disorders of mineral metabolism. Vitamin K plays an important role in vascular calcification in CKD by regulating vitamin K dependent proteins (VKDPs) such as matrix G1a protein (MGP), growth arrest specific gene 6 (Gas-6) and osteocalcin. In this review we will discuss the physiologic role of vitamin K in vascular calcification and how in kidney disease, disorders of vitamin K lead to accelerated calcification. Furthermore we will discuss how vitamin K deficiency and oral anticoagulation (vitamin K inhibitors) further accelerate vascular calcification in the CKD population leading to premature cardiac disease and calcific uremic arteriopathy (CUA).