Acute Tumor Lysis Syndrome Induced by Corticosteroids (pp. 83-94)
Authors: Duzova, Ali (Hacettepe University Faculty of Medicine, Ankara, TURKEY)
Abstract: Acute lysis syndrome (ATLS) is a well recognized oncologic emergency. ATLS consists of hyperkalemia, hyperphosphatemia, hypocalcemia, hyperuricemia and acute renal failure. It commonly occurs in patients with non-Hodgkins lymphoma (NHL) and acute lymphoblastic leukemia (ALL) with the administration of combined cytotoxic chemotherapy. The major risk factors are large tumor burden, rapid tumor growth rates, high LDH levels, and compromised baseline renal function.