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01.Vertebral Compression Fractures from Spinal Metastases: Imaging and Application of Kyphoplasty and Vertebroplasty (p. 63-71)
02.Bone Metastases and Quality of Life (p. 117-131)
03.Defining Oncologic Spinal Instability (p. 55-61)
04.Bisphosphonates in the Management of Bone Metastases (p. 91-97)
05.Evaluation of Photodynamic Therapy as Treatment for Spinal Metastases (p. 83-91)
06.Less Invasive Surgical Approaches for Spine Metastases (p. 73-81)
07.Management of Malignant Spinal Cord Compression (p. 43-53)
08.Palliative Radiotherapy of Bone Metastases and Pain Flare (p. 105-115)
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Editorial - Bone Metastases (p. 1-2) $0.00
Authors:  Arjun Sahgal, Edward Chow, Lori Holden and Joav Merrick

This special issue represents a compilation of selected research, ideas and philosophy of care by physicians at the University of Toronto in Canada, who work in the field of bone metastases.
Bone metastases are a common event for cancer patients and highlighted in this issue is research in the field of both bone metastases and malignant spinal cord compression (MSCC). Details as to an innovative and unique clinical research program dedicated to palliative radiation oncology at the Odette Cancer Centre, Sunnybrook Health Sciences Centre and specifically a multidisciplinary clinic for bone metastases, is provided in the paper by Nguyen et al. The development of this program introduces an effective strategy to conduct research in palliative radiation oncology, and many of the papers in this special issue represent research derived from this clinic. One highlight is the description of state of the art research done for a new approach to the management of spinal metastases using stereotactic radiotherapy techniques. The following papers describe research performed to further our knowledge into radiation, surgical and medical management of bone metastases and MSCC.
A few papers presented in this issue represent research in symptom control and quality of life for bone and brain metastases. This is an evolving active field of research as greater emphasis is being placed into understanding the goals of improving not only a patientís survival, but the ability for therapies to improve the quality of a patient's life.
Beyond management and technical research, studies aimed at bettering our understanding of what patient's in palliative care face at the end of life are highlighted in several papers. In particular, some leading research in patient and physician communication with respect to palliative patients, and models to predict survival so that we can better understand when to focus more of symptom control as opposed to cancer control are provided.
Overall this special issue is aimed at providing an overview of research conducted within the University of Toronto in the field of bone metastases to provide
the reader with cutting edge thinking in the field. As cancer patients live longer, we foresee greater efforts in this area of cancer research to better serve our patients at the end of their life. 

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Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

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Editorial - Bone Metastases (p. 1-2)