Authors: (V. De Re, M.P. Simula, L. Caggiari, A. Pavan, V. Canzonieri, R. Cannizzaro, Farmacologia Sperimentale e Clinica DOMERT, Centro di Riferimento Oncologico, IRCCS, Aviano, Pordenone, Italy)
Abstract: Proteomic technologies are used with increasing frequency in the scientific community. In this review we would like to highlight their use in celiac disease. The available techniques that include two-dimensional gel electrophoresis, mass spectrometry, antibody and tissue arrays, have been used to identify proteins or protein expression changes specific of gut tissue from patients with celiac disease. A number of studies have employed proteomic methodologies to look for diagnostic biomarkers in body fluids or to examine protein expression changes and posttranslational modifications during signaling. The fast technological development of technologies, along with the combination of classic techniques with proteomics, will lead to new discoveries which will consent a better understanding of the pathogenesis of celiac disease and its complications (i.e. refractory CD and cancer), and to possibily indicate targets for an early diagnosis of CD complications and for specific terapeutic approaches.