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Multidimensional chromatography: an essential tool for proteomics pp. 175-180 $100.00
Authors:  (Chiara Cavaliere, Eleonora Corradini, Patrizia Foglia, Piero Giansanti, Roberto Samperi and Aldo Laganą, Department of Chemistry, SAPIENZA Universitą di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy)
Abstract:
It is well established that high doses of ionising radiation, such as used in
radiotherapy, increase risk of cardiovascular diseases (CVD). Observed effects include direct damage to the coronary arteries, marked diffuse fibrotic damage
of the pericardium and myocardium, pericardial adhesions, stenosis of the
valves and microvascular damage [1, 2]. In contrast, there are considerable
uncertainties concerning health effects of low doses of ionising radiation on
heart. The need to explore potential biological and physiological effects at low doses is being increasingly acknowledged as the plans for new nuclear power
plants and novel medical applications using low-dose radiation are emerging.
The data concerning CVD risk after occupational and environmental
exposures to low doses of ionising radiation are controversial. Radiation
workers in the Chernobyl liquidator cohort show increased risk for ischemic heart disease [3]. Among employees at British Nuclear Fuels as well as in
Canadian nuclear worker cohort and other occupationally radiation-exposed
groups there is evidence for an increasing trend concerning circulatory disease mortality with dose [4, 5]. In contrast, no statistically significant increase in
circulatory disease mortality due to inhaled radon or external γ-irradiation and
its progenies could be observed in German uranium miners. However, while the risk for ischemic heart disease showed no increase, the rate of acute
myocardial infarction was enhanced with radon dose [6]. 


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Multidimensional chromatography: an essential tool for proteomics pp. 175-180