Authors: (Catherine Ulbricht, Dilys Burke, Dawn Costa, Ashley Doshi, Richard Isaac, Katie Nummy, Idalia Rychlik, Michael David Seidman, Jill M. Grimes Serrano, Diem Tran, Minney Varghese and Wendy Weissner)
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Abstract:
Objective: To evaluate the scientific evidence on Black seed including history, folkloric precedent, expert opinion, pharmacology, dosing, interactions, adverse effects, and toxicology. This review serves as a clinical support tool. Methods: Electronic searches were conducted in ten databases, 20 additional journals (not indexed in common databases), and bibliographies from 50 selected secondary references. No restrictions were placed on language or quality of publications. All literature collected pertained to efficacy in humans, dosing, precautions, adverse effects, use in pregnancy/lactation, interactions, alteration of laboratory assays, and mechanisms of action. Standardized inclusion/exclusion criteria are utilized for selection. Grades were assigned using an evidence-based grading rationale.
Results: The review found that there was limited high- quality human evidence supporting the safety and effectiveness of Black seed. The available human and non-human studies show possible effectiveness as treatment for a variety of disorders including, but not limited to, abdominal pain, inflammation, anxiety, boils, colon cancer, diarrhea, headache, hyperlipidemia, and nasal congestion,
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