Interplay of Leptin with the Stress System Components pp. 1-32
Authors: (George Soulis, Efthymia Kitraki, Ippokratio General Hospital, Athens, Greece, and others)
Abstract: During the last decade research in the field of metabolism has incorporated studies on the interactions of leptin with components of the stress response system and their impact in situations such as the metabolic syndrome. Today, accumulating evidence suggest the existence of a bidirectional interplay between leptin and stress hormones of sympathoadrenal or neuroendocrine origin that extends beyond the metabolic control. In the central nervous system, the aforementioned interplay appears to be also implicated in the neuroendocrine and behavioral stress response, synaptic plasticity, mood and neuroprotection. In the periphery, leptin - stress hormones‘ interactions are essential in adiposity and obesity-related hypertension. These interactions are influenced by sex hormones. On most occasions leptin and glucocorticoids show antagonistic effects, whereas estrogens mimic some of the central leptin actions. Furthermore, leptin‘s trophic and programming effects on the developing organism are amenable to environmental stimuli including stress.