Gender Difference in Leptin Production and Leptin Sensitivity pp. 107-122
Authors: (Haifei Shi, Cellular, Molecular and Structural Biology Program, Department of Zoology, Miami University, Oxford, Ohio, USA)
Abstract: Obesity and its related health disorders are increasing. Leptin, a hormone product of the obese (ob) gene, is proportional to peripheral energy stores, provides negative feedback signals to the central nervous system, plays a key role in the regulation of caloric intake and energy expenditure, and thus regulates body weight and body fat.
Men and women become overweight or obese in different ways, and suffer different consequences. Specifically, men and women differ in terms of how and where they store body fat, the levels of leptin they synthesize and secrete in proportion to their body fat, and the way they respond to endogenous and exogenous leptin to regulate energy balance and body fat. Leptin is mainly produced in adipose (fat) tissues, and its level is associated with adiposity. Interestingly, serum leptin levels are greater in females than in males with equivalent amount of body fat.