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| The Role and Application of Leptin in Control of Female Reproductive Functions pp. 123-140 |
$100.00 |
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Authors: (Alexander V. Sirotkin, Institute of Genetics & Reproduction, Animal Production Research Centre, Luzianky, Slovakia, and others)
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Abstract:
Leptin, a product of adipose and some other tissues, which production is promoted by food intake and other stimuli, can be an important hormone through which different external factors affect reproductive processes. Leptin can affect reproduction through the hypothalamo-hypophysial system and by direct action on gonads. Regarding the effects of leptin at CNS level, some reports demonstrated a stimulatory influence of leptin on production of hypothalamic GnRH and hypophysial hormones. Regarding direct effects on the ovary, leptin was found to affect growth, ovulation of ovarian follicles and corpus luteum development, ovarian cell proliferation, apoptosis, secretory activity, oocyte maturation and developmental competence, as well as fecundity. Extra- and intracellular mechanisms of leptin action at central and ovarian level can include hormones (GnRH, gonadotropins and other pituitary hormones, pro-opiomelanocortin, kisspeptin and neuropeptide Y, steroid and nonapeptide hormones, prostaglandins, IGF-I/IGFBP system, VEGF and their receptors), several protein kinases and transcription factors. Serum leptin level can be used to predict development of a number of reproductive disorders including ovarian cancer. |
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