Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Proteins » Leptin: Hormonal Functions, Dysfunctions and Clinical Uses Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Theory of Literature
$243.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Interaction Between Leptin and Gut Hormones in the Regulation of Food Intake and Body Weight pp. 187-208
Tell A Friend
 
Tell someone you know about this product.
Interaction Between Leptin and Gut Hormones in the Regulation of Food Intake and Body Weight pp. 187-208 $0.00
Authors:  (Tooru M. Mizuno, Tooru M. Mizuno, Ph.D., Department of Physiology, University of Manitoba, Winnipeg, Manitoba, R3E 0J9, Canada, and others)
Abstract:
Leptin is the adipocyte-derived hormone which is released into the circulation in direct proportion to adiposity and participates in the long-term regulation of body weight. Leptin treatment is effective in reversing metabolic impairments in leptin-deficient mice and humans. However, the majority of human obesity is associated with elevated circulating leptin levels and leptin resistance, limiting the weight-lowering effect of leptin. Therefore, establishment of a strategy to reverse leptin resistance is urgent. Meal-associated gastrointestinal hormones have been proven to be effective in reducing short-term food intake. However, the effect of gastrointestinal hormones on long-term food intake and body weight is limited in both magnitude and duration in general. Leptin and gastrointestinal satiety-promoting hormones reduce food intake and body weight by activating the central nervous system (CNS) cells through their synergistic interaction. Combined treatment of leptin and gastrointestinal hormone produces greater reductions in food intake and body weight compared to the treatment with leptin alone or gastrointestinal hormone alone in both normal and leptin-resistant animals. Pre-treatment with gastrointestinal hormone restores leptin-induced activation of CNS signaling in obese leptin-resistant animals. Thus, leptin amplifies feeding inhibition and neural activation produced by gut-derived hormones, suggesting that leptin may increase the efficacy of gastrointestinal meal-related signals. Alternatively, gut-derived hormones may enhance responsiveness to leptin in CNS cells. It is proposed that the interactions between leptin and gastrointestinal hormones participate in the regulation of both short-term feeding and long-term body weight and that the combination treatment of leptin and gastrointestinal hormones is an effective strategy for the treatment of obesity, in particular leptin-resistant obesity. 


Available Options:
Version:

  Open Access item.
  Click below PDF icon for free download.

  

This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2021

Interaction Between Leptin and Gut Hormones in the Regulation of Food Intake and Body Weight pp. 187-208