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| Adipokines in Human Pregnancy: The Role of Leptin and Adiponectin pp. 239-282 |
$100.00 |
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Authors: (Shali Mazaki-Tovi, Edi Vaisbuch, Juan Pedro Kusanovic, Roberto Romero, Perinatology Research Branch, Hutzel Women’s Hospital, Bethesda, Maryland, and others)
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Abstract:
During the last decade, accumulating evidence has demonstrated that adipose tissue is an important endocrine organ involved in the regulation of systemic metabolism, as well as in the orchestration of the immune response.[1-9] Adipose tissue can exert its systemic effects through several mechanisms, the most important of which is the secretion of bioactive mediators from adipocytes and other cells, collectively termed ―adipokines.‖ The adipokines family includes structurally and functionally diverse proteins. Indeed, the adipokines encompass cytokines [e.g. tumor necrosis factor (TNF)-α [10-14] and interleukin (IL)-6 [15-20], chemokines (e.g. monocyte chemoattractant protein-1), [21;22] mediators of vascular hemostasis (e.g. plasminogen activator inhibitor-1), [23-25] blood pressure (e.g. angiotensinogen), [26;27] and angiogenesis (e.g. vascular endothelial growth factor), [28;29] as well as hormones regulating glucose homeostasis (e.g. leptin, [30-36] adiponectin, [37-41] resistin, [42-46] visfatin [47] and retinol binding protein 4 [48-51]). |
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