Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Immunology » Regulatory T Cells Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
_Cancer Research Journal - This journal ceased publication after 4#4 (2010). Back Issues are available.
$195.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to The Role of Regulatory T Cells in GVL and GVHD, pp. 117-135
Tell A Friend
 
Tell someone you know about this product.
The Role of Regulatory T Cells in GVL and GVHD, pp. 117-135 $100.00
Authors:  (Abdullah Alsuliman, Paula Garland, Katayoun Rezvani, Imperial College, Hammersmith Campus, London, United Kingdom)
Abstract:
The recognition and elimination of malignant cells by donor derived immune effector cells, the so-called graft-versus-leukemia effect (GVL), is key to the success of Allogeneic Hematopoietic Stem Cell Transplantation (AHSCT) in hematological malignancies. The ongoing challenge limiting the success of AHSCT is the maximization of this powerful GVL effect, while minimizing attack of the donor immune cells against the host normal tissue, the so-called graft-versus-host disease (GVHD). The role of CD4+CD25+FOXP3+ regulatory T cells (Treg) in the promotion of peripheral tolerance to self and thus the aversion of autoimmunity is now widely accepted. Furthermore, increasing evidence support their role in modulating alloresponses in the stem cell transplant setting, demonstrating that Tregs are critical players both in the engraftment of donor stem cells and the abrogation of allo-reactive responses that can result in GVHD. Importantly evidence from both murine models and human data suggests that Tregs dampen the alloresponse to host, thereby ameliorating the severity of GVHD without an apparent loss of useful GVL effect. This observation has sparked much research interest into both the underlying mechanisms by which Tregs mediate this effect and ways in which their function can be harnessed and translated into therapies to improve AHSCT outcomes. In this review we seek to summarize the existing data on the role of regulatory T cells in the stem cell transplant setting and examine how their manipulation might be incorporated as a useful technique to reduce GVHD following allogeneic stem cell transplantation. 


Available Options:
Version:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2021

The Role of Regulatory T Cells in GVL and GVHD, pp. 117-135