Regulatory T cells and Tumor Immunity in the Tumor Microenvironment, pp. 153-168
Authors: (Lisong Shen, Matthew R. Thompson, Dakang Xu, Department of Clinical Laboratory, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China, and others)
Abstract: A strong relationship exists between regulatory T (Treg) cells and the development and progression of cancer. Increasingly, evidence suggests that Treg cells can migrate into tumors and suppress effective antitumor responses in the tumor microenvironment. The critical question that needs to be addressed is the mechanism of action of these Treg cells in vivo. In this chapter, we consider the nature and characteristics of Treg cells in the tumor microenvironment, including dynamic processes of Treg recruitment, activation and induction during tumor pathogenesis and their potential mechanism for multiple suppressive effects. Enhancing our understanding of the underlying molecular mechanisms will offer an insight into how Treg cell function can be manipulated more effectively for antitumor therapy.