Regulatory T Cells in Allergic Disorders and Immunomodulation, pp. 247-250
Authors: (Kei-ichi Yamanaka, Department of Dermatology, Mie University, Graduate School of Medicine, Edobashi, Tsu, Mie, Japan)
Abstract: The immune system protects the host from infection and exogenous stimuli using innate and acquired immune systems and is critical to maintaining health. These stimuli lead to type 1 helper T cell (Th1) and/or Th2 type cytokine secretion according to the character of the exogenous or endogenous stimuli. In addition, FoxP3＋(forkhead box P3＋) CD4＋CD25＋regulatory T cells: natural regulatory T cell (nTreg), IL-10 producing regulatory T cells (Tr1), and Th17 cells play a pivotal role in this immune balance triggering immune suppression and stimulation. Altogether they form a four-way balance. In allergic diseases including atopic dermatitis (AD) and nasal allergy, it is understood that the cytokine profile comprises Th2 dominant, and this milieu gives rise to phenotypical abnormality and pathologic conditions including cellular infiltration and overproduction of IgE.