On/Off-Switched Molecular Recognition by a Smart Aminopurine-Imprinted Polymer pp. 283-300
Authors: (Songjun Li, Ashutosh Tiwari, Mani Prabaharan, Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, China, and others)
Abstract: The ‗on/off‘-switched molecular recognition by a smart imprinted polymer (MIP-T) was presented in this chapter. The smart MIP-T was prepared using PNIPA as the thermosensitive element and 2-aminopurine as the template. The thermal phase transition of PNIPA induced a self-switching ability in the prepared polymer. At a relatively low temperature (such as 20 oC), the MIP-T was capable of highly specifically recognizing the imprint species, i.e., 2-aminopurine. However, above the transition temperature, the MIP-T did not demonstrate significant resolution for 2-aminopurine compared with its analogue 2-amino-6-methylpurine. Such temperature-responsive recognition, in nature, was comparable to an on/off-switched process, which allows an efficient self-regulation in the molecular recognition behavior.