Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Biology - General » Advances in Medicine and Biology. Volume 9 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects
$73.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Chapter I. Overview on the Properties and Functions of the Core Protein of Hepatitis C Virus (HCV), pp. 1-47
Tell A Friend
 
Tell someone you know about this product.
Chapter I. Overview on the Properties and Functions of the Core Protein of Hepatitis C Virus (HCV), pp. 1-47 $100.00
Authors:  (Roland Ivanyi-Nagy, Zuzanna Makowska, Marcelo Lopez Lastra, Jean-Luc Darlix, Molecular Parasitology Group, The Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom, and others)
Abstract:
The hepatitis C virus (HCV) core protein is a small, highly basic RNA-binding protein that presumably coats and protects the viral genomic RNA, forming the virion nucleocapsid. Core protein specifically associates with the structured 5‟ and 3‟ untranslated regions (UTRs) of the viral genome and, due to its RNA chaperone activity, induces essential structural rearrangements in the target RNA. Binding to the 5‟ UTR regulates viral polyprotein synthesis, while chaperoning the 3‟ UTR may influence genome replication and possibly genetic variability. Recent results show that HCV and other flavivirus core proteins belong to the class of intrinsically unstructured proteins (IUPs). Due to its inherent flexibility, core protein participates in a variety of specific/weak affinity protein-protein interactions with cellular targets, thereby possibly exerting an influence on a number of vital processes, including regulation of cellular transcription, apoptosis, signaling and immunomodulation. As a result, core has been ascribed to play a major role in HCV infection-associated pathologies, such as hepatic steatosis, type 2 diabetes and malignant transformation leading to hepatocellular carcinoma, but this is still controversial. Lack of an efficient model system for HCV virion production had for a long time precluded direct characterization of core protein function in virus assembly and budding. The recent development of a cell culture system supporting the complete HCV replicative cycle created conditions for an improved understanding of HCV biology. As a highly expressed and conserved viral antigen, core protein is ideally suited to occupy a central role in future treatment possibilities, either for vaccination or as a small molecule drug target. In this chapter we describe the current status of knowledge about the multifunctional role of HCV core protein in virion structure, viral replication and virus-host cell interactions that might be central to pathogenesis during persistent HCV infection. Furthermore, we examine the reasons for the lack of anti-core protein drug candidates in the RandD pipeline and argue that efforts in this direction should be of high priority. 


Available Options:
Version:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Chapter I. Overview on the Properties and Functions of the Core Protein of Hepatitis C Virus (HCV), pp. 1-47