Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Biology - General » Advances in Medicine and Biology. Volume 9 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Hepatitis C: Symptoms, Diagnosis and Treatment, pp. 135-158
Tell A Friend
Tell someone you know about this product.
Hepatitis C: Symptoms, Diagnosis and Treatment, pp. 135-158 $0.00
Authors:  (C. Jochum, J.F. Schlaak, Dept. of Gastroenterology and Hepatology, University Hospital of Essen, Essen, Germany)
The hepatitis C virus (HCV) is a positive-stranded hepatotropic RNA virus of the Flaviviridae family. Its genome which contains 9600 nucleotides is packed in a nucleocapsid (core). This is covered by an envelope consisting of a lipid layer with viral glycoproteins that are involved in the entry process of the virus. The RNA encodes for a polyprotein which is approximately 3,000 amino acids long and is cleaved into 10 different HCV proteins. These proteins include structural proteins (core protein and the envelope glycoproteins E1 and E2) and the non-structural proteins p7, NS2, NS3, NS4A, NS4B, NS5A and NS5B (Figure 1) [1,2].
NS2 functions as a metallo-cysteine protease while NS3 is a serine helicase and protease. NS4A is a NS3 protease co-factor and NS5B resembles the RNA dependent RNA polymerase. As these proteins are required for proper assembly of the virus they are targets for potential antiviral drugs. The function of NS4B and NS5A and the ion channel p7, however, are not well understood. The polyprotein is cleaved by viral proteases (non-structural proteins) and host proteases (envelope and core proteins), respectively. Replication is performed using the RNA dependent RNA polymerase that produces a minus-stranded RNA intermediate which is then translated in the plus-stranded RNA. The HCV RNA-dependent RNA-polymerase lacks a proofreading function which, together with the high viral production rate, is responsible for the high rate of HCV quasispecies that is found in an infected individual. So far, 6 different genotypes of HCV (genotype 1-6) have been described which can be divided into more than 50 subtypes (genotype 1a, 1b, 2a, etc.) [3,4]. 

Available Options:

  Open Access item.
  Click below PDF icon for free download.


This is an Open Access item. Click above PDF icon for free download.
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Hepatitis C: Symptoms, Diagnosis and Treatment, pp. 135-158