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Cell-Based Therapy of Liver Cirrhosis, pp. 1-32 $100.00
Authors:  (Dong-Sheng Li, Ya Liu, Sheng-Ming Zhang, Yong-Tang Feng, Long-Jun Dai, Hubei Key Laboratory of Embryonic Cell Research, Yunyang Medical College, Shiyan, China, and others)
Abstract:
Hepatic cirrhosis is the end-stage of chronic liver diseases. The majority of patients
with hepatic cirrhosis die from life-threatening complications at early age. Liver
transplantation has been the most effective treatment for patients with hepatic cirrhosis.
Since liver transplantation is critically limited by the shortage of available donor livers,
searching for an effective alternative therapy has attracted great interest in preclinical
studies. The encouraging advances in stem cell research have paved the way towards the
treatment of the end-stage of chronic liver diseases. In view of the pathogenic
fundamentals of hepatic cirrhosis, cell-based treatment should be aimed to complement
or replace damaged liver cells and to correct the imbalanced extracellular matrix
regeneration/degradation. Understanding the transition of hepatocyte regeneration to
hepatic fibrogenesis during chronic liver injury could guide the appropriate utilization of
cell-based therapy. This chapter is intended to describe the characteristics and therapeutic
potential of various stem cells, including hepatocytes, liver progenitor cells,
hematopoietic stem cells, mesenchymal stem cells, embryonic stem cells and induced
pluripotent stem cells. Since autologous adult stem cells have the least obstacles for
clinical application, their potential interventions on cirrhosis are especially illustrated in
terms of the cellular and molecular mechanisms of hepatic fibrogenesis. 


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Cell-Based Therapy of Liver Cirrhosis, pp. 1-32