Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Biology - General » Advances in Medicine and Biology. Volume 7 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Central Asia: Perspectives and Present Challenges
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Exercise & Nutrition: Implications for Leg Muscle Growth in Humans, pp. 63-86
Tell A Friend
Tell someone you know about this product.
Exercise & Nutrition: Implications for Leg Muscle Growth in Humans, pp. 63-86 $100.00
Authors:  (Jared M. Dickinson, Blake B. Rasmussen, Sealy Center on Aging, Center for Rehabilitation Sciences, University of Texas Medical Branch, Galveston, Texas)
Skeletal muscle is a highly dynamic tissue that undergoes adaptive remodeling in
response to a variety of stimuli. The ability of skeletal muscle to adapt is ultimately
governed by the interplay between protein synthesis and protein breakdown and
advances in the use of stable isotope tracers to monitor changes in muscle protein
metabolism have provided a means to gain important insight into the adaptive state of
skeletal muscle. Specifically, two key anabolic stimuli, resistance exercise and nutrition,
have been shown to increase leg muscle protein synthesis and therefore have been
suggested as potential therapies for human skeletal muscle. In this chapter, we discuss
the human-based scientific literature as it pertains to the independent and combined
effects of acute resistance exercise and nutritional interventions on leg muscle protein
synthesis. Further, while the cellular mechanisms regulating muscle protein synthesis
have yet to be fully resolved, we highlight recent human investigations that have
demonstrated a key role for the mammalian target of rapamycin (mTOR) signaling
pathway in regulating muscle protein synthesis following both acute resistance exercise
and nutrition, primarily in the form of essential amino acids. We propose that ingesting
essential amino acids shortly after completing a bout of resistance exercise promotes
greater increases in leg muscle protein synthesis compared to that elicited independently
by each stimulus. In addition, it is clear that the mTOR signaling pathway plays a vital
role in this synergist anabolic effect. We suggest that when performed chronically, the
use of resistance exercise coupled with appropriate nutritional strategies may be
beneficial to overcome the deleterious effects associated with conditions of muscle
wasting and decreased muscle function such as aging, injury, and disease. 

Available Options:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Exercise & Nutrition: Implications for Leg Muscle Growth in Humans, pp. 63-86