Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Biology - General » Advances in Medicine and Biology. Volume 7 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Doxycycline: Medical Uses and Effects
$82.00
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Primary Biliary Cirrhosis: Pathology and Pathogenesis, pp. 109-144
Tell A Friend
 
Tell someone you know about this product.
Primary Biliary Cirrhosis: Pathology and Pathogenesis, pp. 109-144 $100.00
Authors:  (Yasuni Nakanuma, Yasunori Sato, Maylee Hsu, Hiroko Ikeda, Motoko Saski, Kenichi Harada, Kanazawa University Graduate School of Medicine, Kanazawa, Japan, and others)
Abstract:
Primary biliary cirrhosis (PBC) is an autoimmune liver disease which mainly affects
middle to old aged females. Clincially, PBC is a chronic cholestatic liver disease, and the
term PBC was established in 1950. Since then, many clinical, pathological and
immunological features have been shown. The small intrahepatic bile ducts are a main
target tissue of PBC and hepatocytes are also simultaneously attacked variably.
Serologically, antimitochondrial antibodies (AMA) are characteristically detected in the
patients serum, and the target antigens of AMA are shown to be pyruvate dehydrogenase
E2 complex located in the inner membranes of mitochondria. The term chronic
nonsuppurative destructive cholangitis (CNSDC) more accurately reflects the
pathogenesis of this disease, and mmunopathological features of the bile ducts showing
CNSDC are also detailed. Furthermore, T cell mediated cytotoxicity against biliary
epithelial cells and biliary innate immunity are responsible for the progressive bile duct
damages in PBC. Along with the progressive bile duct damage, chronic cholestasis,
biliary fibrosis and then cirrhosis develop and the patients die of hepatic failure. PBC is a
fatal disease and liver transplantation is only a curable therapy. 


Available Options:
Version:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Primary Biliary Cirrhosis: Pathology and Pathogenesis, pp. 109-144