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Vitamin C Absorption and Transportation in the Body and its Neuroprotective Effect pp. 167-180 $100.00
Authors:  (Amir Zarebkohan, Jamal Ghorbi Naini, Medical Nanotechnology Department, Shahid Beheshti Medical University, Tehran, Iran, and others)
Abstract:
Vitamin C (Ascorbic acid) is a water-soluble, hexonic sugar acid, that with glutathione (GSH) attendance are the two most abundant low-molecular-weight antioxidants in mammalian brain tissue.
Ascorbic acid has two dissociable protons, with pKa values of 4.2 and 11.8, and, thus, is a monovalent anion, ascorbate, at physiological pH. Its enediol structure enables it to be an electron donor, via loss of two electrons to form its final oxidation product, dehydroascorbate. Ascorbate and dehydroxy ascorbic acid (DHA) are in equilibrium in CNS microenvironment, together. The best-known functions of ascorbate, is antioxidant and free radical scavenger in the CNS, which crucial for the brain survival. Moreover, vitamin C has a neuromodulatory effect on brain neurons. As yet, 4 mechanisms have been discovered for ascorbate transportation in the human body, that between them Sodium Dependent Vitamin C Transporter 1 and 2 (SVCT1, SVCT2) is the most important. In this chapter we have discussion on vitamin C transportation mechanisms and neuroprotection effects in central nervous system. 


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Vitamin C Absorption and Transportation in the Body and its Neuroprotective Effect pp. 167-180