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The Functional Role of the Glucocorticoid Receptor (Gr) and Nur77 in Thymocyte Development pp. 67-86 $100.00
Authors:  (Noriko Tosa, Takahiro Fukumoto, Tadaaki Miyazaki, Institute for Animal Experimentation, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan, and others)
Abstract:
Nuclear receptors are involved in various aspects of intracellular signal transduction on a range of tissue and play an important role as regulators in numerous essential biological functions. In the thymus, these nuclear receptors also participate in positive or negative selection during T cell development.
In particular, the glucocorticoid receptor (Gr) and Nur77 play central roles in apoptosis induction mediated by the T cell receptor (TCR) in mature thymocytes or glucocorticoids (GCs) in immature thymocytes, respectively. Recently, we demonstrated that death-associated protein 3 (DAP3) was critical for TCR-mediated induction of apoptosis downstream of Nur77 in immature thymocytes. The DAP3 is an evolutionarily conserved GTP binding protein that plays a number of roles in normal mitochondrial physiology and in apoptosis induced via the tumor necrosis factor (TNF) family of death receptors. This chapter reviews recent studies of the signal transduction mediated by Gr and Nur77 in thymocyte development, focusing on signaling molecules, such as DAP3, involved in the signaling pathways of Gr or Nur77. Briefly, discussion which have attracted attention are summarized as follows: 1) signaling molecules interacting with Gr or Nur77, 2) the functional role of Gr or Nur77 in subcellular localization, 3) the function of genes subject to induction by Gr or Nur77, 4) crosstalk and its physiological importance in the signal transduction mediated by Gr and Nur77. 


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The Functional Role of the Glucocorticoid Receptor (Gr) and Nur77 in Thymocyte Development pp. 67-86