Nitric Oxide: A Tool to Block Nuclear Receptor Activity pp. 87-102
Authors: (Klaus-Dieter Spindler, Martin Laschak, Marcus V. Cronauer, Institut für Allgemeine Zoologie und Endokrinologie, Universität Ulm, Ulm, Germany)
Abstract: Nitric oxide (NO), a free radical gas, is an omnipresent intercellular messenger in all vertebrates. Originally described as a cardiovascular signal molecule (Ignarro, 1989) NO elicites a variety of physiological functionslike muscle contractility, platelet aggregation, metabolism, neuronal activity, and immune responses in a broad range of tissues. The molecule originates from the action of nitric oxide synthases (NOS) which are either induced (iNOS) or constitutively expressed (eNOS, nNOS). The underlying mechanisms of NO action are primarily an elevation of guanosine 3',5'-cyclic monophosphate due to the stimulation of soluble guanylyl cyclase, inhibition of mitochondria respiration and nitrosylation of proteins (Pacher et al., 2007; Gao, 2010).