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AR Has a Potential Role in Mediating the Serotonin Synthesis Mechanism pp. 113-120 $100.00
Authors:  (Takahiro Fukumoto, Noriko Tosa, Tadaaki Miyazaki, Research Center for Infection-associated Cancer, Institute for Genetic Medicine, HokkaidoUniversity, Sapporo, Japan, and others)
Abstract:
Nuclear receptors are a class of proteins that have the ability to directly bind to DNA and regulate gene expression, and these receptors are classified as transcription factors. This report focuses on a new function of AR (androgen receptor). Androgen receptors (ARs) belong to the steroid receptor family and play an essential role in the generation and development of the prostate. Androgen receptors have similar conserved domains that are composed of an NTD (N-terminal domain), a DBD (DNA-binding domain), and an LBD (ligand-binding domain). The NTD works stabilize bound androgen and the AR-LBD mediates the interaction between AR and other proteins, which include Hsps (heat-shock proteins). In the absence of androgen, AR remains in the cytoplasm in an inactive form. After AR binds to androgens, activated AR can bind with other signal molecules and form functional complexes. Then, the complex translocates to the nucleus and regulates the gene expression for androgen regulated genes. Recently, some research has shown that AR can interact with DDC (L-dopa decarboxylase), a key molecule for serotonin (5-HT) synthesizing. Serotonin is a well known neurotransmitter but has been mentioned in the relationship with the generation of the prostate. Then, we introduce here that AR can regulate prostate cancer progression via the serotonin synthesis process.
A suggested rewrite of the previous sentence, placed here to avoid ambiguity: This paper suggests that AR may play a role in regulating the progress of prostate cancer via the serotonin synthesis process. 


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AR Has a Potential Role in Mediating the Serotonin Synthesis Mechanism pp. 113-120