Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Molecular Biology » Nuclear Receptors Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Fetal Alcohol Syndrome: Recognition, Differential Diagnosis and Long-Term Effects
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Peroxisome Proliferator-Activated Receptors: Nuclear Receptors with Pleotropic Actions pp. 127-174
Tell A Friend
Tell someone you know about this product.
Peroxisome Proliferator-Activated Receptors: Nuclear Receptors with Pleotropic Actions pp. 127-174 $100.00
Authors:  (Nik Soriani Yaacob, Mohd. Nor Norazmi, Department of Chemical Pathology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, Kubang Kerian, Kelantan, Malaysia)
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors that regulate gene expression and are modulated by interaction with corepressors and coactivators. Natural and synthetic ligands promote heterodimerization of PPARs with the retinoid-X-receptor (RXR), facilitating their binding to consensus DNA sequences on target genes. To date, three subtypes of PPAR have been identified , , and  ; with the subtype consisting of two distinct functional isoforms, 1 and 2. Although structurally similar, the PPAR subtypes have specific tissue distribution and functions. PPARs regulate multiple cellular functions, such as cell proliferation, the immune response and lipid metabolism and therefore their ligands have been investigated for their potential use in various clinical settings. For example, the PPARligands comprising the thiazolidinedione class of drugs have been used for the management of type 2diabetes. The potential use of PPAR ligands in autoimmune diseases is also being investigated whereas the specific role of PPARs in tumor development is still controversial. Despite some drawbacks, PPARs still remain as potential therapeutic targets for various conditions and currently dual and pan agonists are being investigated for this purpose. Taken together, the role of PPARs in various cellular processes and disease pathogenesis still requires further investigation and continues to be an exciting field of research. This review will attempt to provide examples of some of the recent findings in these areas of research, highlighting the mechanisms of action and the potential use of PPAR agonists as well as the challenges that still need to be addressed. 

Available Options:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

Peroxisome Proliferator-Activated Receptors: Nuclear Receptors with Pleotropic Actions pp. 127-174