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Heme Oxygenase: The Elegant Orchestration of its Products in Medicine
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Editors: Leo E. Otterbein (Harvard Medical School) and Brian S. Zuckerbraun (University of Pittsburgh School of Medicine)
Book Description:
Heme oxygenase is an enzyme which breaks down heme, the iron-containing oxygen-carrying constituent of the red blood cells. Heme must be synthesized and degraded within an individual nucleated cell, as heme is essential for the maintenance of cellular homeostasis by sensing or using oxygen. Physiological heme degradation is catalyzed by the two functional isozymes of heme oxygenase, heme oxygenase-1 (HO-1) and HO-2, yielding CO, iron, and biliverdin IXƒŃ. Heme oxygenase-1 (HO-1), has potent anti-inflammatory, anti-oxidant and anti-proliferative effects, is up-regulated by multiple stimuli and provides protection against oxidative stress. HO-1 also plays an important role in the regulation of cardiovascular function and is involved in many other diseases such as sickle cell disease. This new book brings together leading research from around the world in this field.

Table of Contents:
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Individual chapters are available for $25 each by sending an email to Nova will provide the chapter for your easy downloading or send it as an email attachment if you prefer.

Preface: The Cain Mutiny;
1.Heme Oxygenase and Human Disease, pp.1-40;
(Mutsuo Yamaya and Shigeki Shibahara (Tohoku University School of Medicine, Sendai, 980-8574 Japan);
2.The Role of Heme Oxygenase-1 Promoter Polymorphisms in Human Disease, pp.41-54;
(Markus Exner et al., Vienna General Hospital, Medical School, Austria);
3.Hematophagy and heme toxicity: What can we learn from natural-born vampires?, pp.55-76;
(Aurelio V Graca-Souza et al., Federal University of Rio de Janeiro, Brazil);
4.Heme Oxygenase-1 in Cardiovascular Biology, pp.77-96;
(Mark A. Perrella, Brigham and Women”¦s Hospital, Boston and Shaw-Fang Yet, Harvard Medical School, Boston);
5.Heme Oxygenase-1: A Potential Modulator of Inflammation and Vaso-occlusion in Sickle Cell Disease, pp.97-112;
(John D. Belcher and Gregory M. Vercellotti, University of Minnesota, Minneapolis);
6.Heme Oxygenase and the Gastroenterological System, pp.113-126;
(Brian S. Zuckerbraun, University of Pittsburgh School of Medicine, Pittsburgh, PA);
7. Novel Functions of Heme Oxygenase Protein, pp.127-140;
(Phyllis A. Dennery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania);
8.Heme Oxygenase-1: A protective gene that regulates inflammation and immunity, pp.141-170;
(Gabriela Silva et al., Instituto Gulbenkian de Ciźncia, Oeiras, Portugal);
9.Heme Oxygenase-1 (HO-1) in Transplantation, pp.171-190;
(Fritz H. Bach et al., Department of Surgery, Harvard Medical School, Boston, MA);
10.Carbon Monoxide-Releasing Molecules (Co-Rms): A Stratagem to Emulate the Beneficial Effects Of Heme Oxygenase-1, pp.191-210;
(Roberto Motterlini and Roberta Foresti, Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom);
11.Heme Oxygenase-1: Linking Signal Transduction to Function, pp.211-224;
(Patty J. Lee, Yale University School of Medicine, New Haven, CT); 12.Role of heme oxygenase-1 and carbon monoxide in ischemia reperfusion injury, pp.225-244;
(Vibha N. Lama et al.);
13.Heme oxygenase-1 and angiogenesis: therapeutic implications, pp.245-270;
(Józef Dulak et al., Jagiellonian University, Kraków, Poland);
14.Reciprocal regulation of heme oxygenases and nitric oxide synthases the modulation of biochemical and physiological functions, pp.271-286;
(Roberta Foresti et al., Northwick Park Institute for Medical Research, Harrow, Middlesex, United Kingdom);
15.Biliverdin Reductase - a reassessment of Its functions in the light of recent discoveries, pp.287-312;
(Mahin D. Maines, University of Rochester Medical Center, Rochester, New York);
16.Antioxidant defense mechanisms By Heme oxygenase and bile pigments, pp.313-332;
(Roland Stocker, University of New South Wales, Sydney, Australia); 17.Heme oxygenase ”V a crucial enzyme in iron and heme homeostasis, pp.333-350;
(R. Tyrrell,University of Bath, Bath, UK);
18.Heme, Heme Oxygenase and Ferritin in Vascular Endothelial Cell Injury, pp.351-376;
(József Balla et al., University of Debrecen, Debrecen, Hungary); 19.Heme Oxygenase-1 Gene Regulation: Transcription Factors and Transduction Pathways, pp.377-400;
(Jawed Alam and Julia L. Cook, Louisiana State University Health Sciences Center, New Orleans, LA);

   Binding: Hardcover
   Pub. Date: 2005
   ISBN: 1-59454-447-6
   Status: AV
Status Code Description
AN Announcing
FM Formatting
PP Page Proofs
FP Final Production
EP Editorial Production
PR At Prepress
AP At Press
AV Available
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Heme Oxygenase: The Elegant Orchestration of its Products in Medicine