Causes and Consequences of Nutritional Iron Deficiency in Living Organisms pp. 245-276
Authors: (Nerea Sanvisens and Sergi Puig, Departamento de Bioquímica y Biología Molecular. Universitat de València. Ave. Doctor Moliner 50, E-46100 Burjassot (Valencia) Spain, and others)
Abstract: Iron is an essential micronutrient for all eukaryotic organisms because it participates as an essential cofactor in multiple biological processes, including respiration, oxygen transport, DNA replication, ribosome biogenesis and photosynthesis. The availability of iron for living organisms is highly restricted due to the low solubility of ferric iron at a physiological pH. Consequently, humans frequently develop iron deficiency anemia (IDA), this being the most common and widespread nutritional disorder in the world. IDA causes learning problems, reduced physical capacity and increased morbidity, particularly in women and children. Multiple strategies including diversification of diet, iron supplementation and fortification of food with iron are simultaneously used to prevent and treat IDA. Recent advances in the mechanisms of human iron acquisition, utilization, regulation and metabolism have proved crucial to understand the causes and consequences of IDA. In the last decade, the microorganism Saccharomyces cerevisiae has importantly contributed to advance in the characterization of the molecular mechanisms that eukaryotic cells use to respond to iron limitation. This knowledge can be used to develop novel strategies to relieve IDA.
Open Access item.
Click below PDF icon for free download.
This is an Open Access item. Click above PDF icon for free download.