Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
  Top » Catalog » Books » Biology » Biology - General » Advances in Medicine and Biology. Volume 27 Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Central Asia: Perspectives and Present Challenges
Shopping Cart more
0 items
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to The Unfolded Protein Response in Renal Transplantation pp. 163-177
Tell A Friend
Tell someone you know about this product.
The Unfolded Protein Response in Renal Transplantation pp. 163-177 $100.00
Authors:  (Nicolas Pallet, INSERM U775 and Paris Descartes University, Paris, France, and others)
Endoplasmic reticulum (ER) stress is a consequence of the accumulation of misfolded proteins in the endoplasmic reticulum, triggering an evolutionarily conserved adaptive response termed the unfolded protein response. When the adaptive response fails, excessive ER stress triggers cell suicide. Important roles for ER-initiated cell death pathways have been recognized for several diseases, including diabetes, hypoxia, nutrient shortage, neurodegenerative and heart diseases. The implications of ER stress are not well recognized in solid organ transplantation, but increasing evidence suggests it has implications in mediating allograft injury. The purpose of this review is to summarize the mechanisms of ER stress and to discuss its implications during tissue injury in kidney transplantation. We will also discuss the possible implications of endoplasmic reticulum stress, beyond the scope of adaptation and cell death, in the modifications of cell functional properties and phenotypic changes. Increasing our understanding of the cellular and molecular mechanisms of acute and chronic allograft damages may lead to the development of new biomarkers and to the discovery of new therapeutic strategies to prevent the initiation of graft dysfunction or to promote tissue regeneration after injury. 

Available Options:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2020

The Unfolded Protein Response in Renal Transplantation pp. 163-177