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A Review of Advances in Multiphase Computational Fluid Dynamics for Microfluidics pp. 179-204 $100.00
Authors:  (Rafael M. Santos, Katholieke Universiteit Leuven, Leuven, Belgium)
Multiphase flow in microchannels has gained much interest in recent years given the numerous emerging applications of microfluidics that promise to provide technological innovations not realizable with conventional channels. Significant developments in the area of micro-scale fabrication in the last decade have allowed researchers to construct increasingly more intricate devices, generally termed Lab-on-a-chip, and used in such diverse fields as: biomedical, analytical chemistry, chemical synthesis, unit operations, among others. Moving forward microfluidics is also envisioned to allow for process intensification of industrial process, hence the production capacity is expected to span from nanoliters to cubic meters, from micrograms to tons. The interest is derived from the fact that gas–liquid two-phase flows in microchannels often exhibit different flow behaviour than macrosized conduits, which allows for the precise control of the trajectory of fluidic particles. At the micro-scale there is increased importance and effect of surface tension forces, while gravitational forces become negligible, and inertial, shearing and drag forces have a limited effect. As a result, multiple unique flow patterns have been identified in microfluidic gas–liquid two-phase flow, including bubbly, slug, ring, churn and annular flow. Transport phenomena, such as heat and mass transfer, and reaction kinetics are also significantly improved at the micro-scale due to the increase in surface to volume ratio. 

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A Review of Advances in Multiphase Computational Fluid Dynamics for Microfluidics pp. 179-204