Nova Publishers
My Account Nova Publishers Shopping Cart
HomeBooksSeriesJournalsReference CollectionseBooksInformationSalesImprintsFor Authors
            
  Top » Catalog » Books » Biology » Proteins » Cystatins: Protease Inhibitors, Biomarkers and Immunomodulators Chapters » My Account  |  Cart Contents  |  Checkout   
Quick Find
  
Use keywords to find the product you are looking for.
Advanced Search
What's New? more
Doxycycline: Medical Uses and Effects
$73.80
Shopping Cart more
0 items
Information
Shipping & Returns
Privacy Notice
Conditions of Use
Contact Us
Notifications more
NotificationsNotify me of updates to Cystatin C in Acute Coronary Syndromes: The Investigation Should Go On pp. 121-142
Tell A Friend
 
Tell someone you know about this product.
Cystatin C in Acute Coronary Syndromes: The Investigation Should Go On pp. 121-142 $100.00
Authors:  (S. Ferraro, G. Marano, B. Suardi, P. La Musta, E.M. Biganzoli, A.S. Bongo, P. Boracchi, SCDO, Cardiologia 2, Ospedale Maggiore, Novara, Italy, and others)
Abstract:
Background: Cystatin C(CC) could contribute adding value to traditional cardiovascular risk factors in the prediction of adverse events in Acute Coronary Syndromes (ACS). Aim of present chapter is to assess the evidence on the prognostic value of CC in ACS patients, by reviewing current literature. Methods and Results: by Pub Med, Embase, Ovid, 29 papers were identified, and 9 longitudinal observational studies in which serum CC was investigated as prognostic
marker in ACS, were selected. The reference populations allowed to classify studies in: Group A) 4 studies with 50-60% of ACS patients and a sample size of 450-1030 patients; Group B) 3 studies on non ST Elevation Acute Coronary Syndromes (NSTEACS) patients and a sample size of 380-1120 patients; Group C) 1 study with 160 ST Elevation
Myocardial infarction (STEMI) and NSTEACS patients; Group D) 1 study with 71 STEMI. Outcome: The end-point was “time to”: 1) cardiovascular death, non fatal myocardial infarction (MI), or stroke, with a median follow up of 3 years; 2) major adverse cardiovascular events (MACE), with a variable median follow up of 3 years, 1 year, and 6 months; 3) death or recurrence of MI, with a median follow up of 3 years, 6 months. Prognostic role: According to results in: - Group A CC levels >1.3 mg/L were a significant risk factor for fatal and non fatal cardiovascular events (HR estimates ranging from 1.72 to 2.27); -Group B, for CC levels >1.25 mg/L, the risk of death was about 12 times greater than that of patients with lower CC levels; in a second study, for CC levels >1.01 mg/L a significant prognostic value on death was found (HR=4.07 (CI:2.16-7.66)). According to the recurrence of AMI evaluated in two studies, only one assessed a significant prognostic role (HR=1.95(CI:1.05-3.63)). For another study , according to a composite endpoint of fatal and non fatal cardiac events, with a CC >0.93 mg/L, a HR of 1.57( CI:1.04-2.49) was shown. For Groups C and D similar results on the prognostic value of CC on MACE were obtained: HR=9.43(CI:4.0-21.8) for CC levels >1.05 mg/L, HR =2.17(CI:1.07-6.98) for CC levels >0.96 mg/L. 


Available Options:
Version:
Special Focus Titles
01.Violent Communication and Bullying in Early Childhood Education
02.Cultural Considerations in Intervention with Women and Children Exposed to Intimate Partner Violence
03.Chronic Disease and Disability: The Pediatric Lung
04.Fruit and Vegetable Consumption and Health: New Research
05.Fire and the Sword: Understanding the Impact and Challenge of Organized Islamism. Volume 2

Nova Science Publishers
© Copyright 2004 - 2022

Cystatin C in Acute Coronary Syndromes: The Investigation Should Go On pp. 121-142