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Cystatin C, Atherosclerosis and Lipid-Lowering Therapy by Statins pp. 187-204 $0.00
Authors:  (T.A. Korolenko, M.S. Cherkanova, E.A. Gashenko, T.P. Johnston, I. Yu. Bravve, Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia, and others)
Abstract:
The search for new serum markers of aging, atherosclerosis, and predictors of cardiovascular emergencies is important in contemporary society. Recently, new nonlipid markers of atherosclerosis and predictors of cardiovascular events were introduced. These markers are related to inflammation and macrophage stimulation, such as cystatin C, matrix metalloproteases (MMPs), and chitotriosidase. Increased serum cystatin C concentration, an alternative measure of renal function, is now suggested as a strong predictor of cardiovascular events. We compared new non-lipid atherosclerosis indexes with common inflammatory (hs-CRP) and lipid markers in elderly persons and patients with atherosclerosis and ischemic heart disease (IHD) who have undergone coronary bypass surgery. Cystatins are known to be very potent endogenous inhibitors of cysteine proteases of the papain superfamily. They form equimolar, tight, and reversible complexes with human cysteine proteases (cathepsins B, H, K, L and S), and express different cellular functions as proteins (cell proliferation, degradation of extracellular matrix, etc.). In
humans, cystatin C, localized predominantly in the extracellular space, was used for early detection of impaired kidney function, as well as a marker in several inflammatory and tumor diseases. The question of whether cystatin C is an atherogenic or protective
protein, as well as its possible role as a marker or predictor in IHD is still not clear. 


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Cystatin C, Atherosclerosis and Lipid-Lowering Therapy by Statins pp. 187-204