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Cystatin C as a GFR Marker in Renal Transplantation: Promises and Challenges pp. 205-214 $100.00
Authors:  (Ingrid Masson, Pierre Delanaye, Christophe Mariat, Service de Néphrologie, CHU de St-Etienne, St-Etienne, France, and others)
Glomerular filtration rate (GFR) is a key parameter to evaluate the function and thereby the quality of the transplanted kidney. Direct measures of the renal elimination of different exogenous GFR (e.g. inulin clearance) are the “gold standard” for assessing GFR. These
techniques are however rarely implemented in routine clinical practice. As an alternative, a number of easy-to-use mathematical equations, incorporating different anthropometrical variables in addition to biological parameters, have been developed to predict (‘estimated GFR’), rather than to directly measure GFR (‘true GFR’).
International guidelines recommended relying on serum creatinine for GFR estimation (1). It has become, however, increasingly evident that serum creatinine, alone or even incorporated into estimating equations, is not an ideal marker of the renal graft function. As a
result, interest has arisen regarding alternative endogenous marker. Among them, cystatine C tends to be regarded as a better marker of GFR than serum creatinine in a variety of different patient populations, including renal transplant patients. 

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Cystatin C as a GFR Marker in Renal Transplantation: Promises and Challenges pp. 205-214