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NotificationsNotify me of updates to Role of Cystatin C in the Neurodegenerative Process and its Possible Use as a Nervous System Biomarker pp. 239-254
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Role of Cystatin C in the Neurodegenerative Process and its Possible Use as a Nervous System Biomarker pp. 239-254 $100.00
Authors:  (Enrique Juarez Aguilar, Fabio Garcia-Garcia, Maria Teresa Croda Todd, Universidad Veracruzana, Mexico, and others)
Abstract:
Cystatin C (CysC) is an alkaline low molecular weight (13 kDa) cysteine protease inhibitor present in all tissues and biological fluids. This molecule has a broad spectrum of biological roles in numerous cellular systems, with growth promoting activity, downregulating of inflammation, anti-viral and anti-bacterial properties. However, its function in the brain is unclear although it has been implicated in the processes of neuronal differentiation and neuroprotection as well as in the repair of nervous system after
damage. Furthermore, deregulation of CysC activity has been implicated with the origin of several brain diseases. Particularly, CysC is genetically associated with late-onset Alzheimer`s disease (AD). Both CysC and amyloid beta (Aβ) protein co-localize in the
parenchymal brain of patients with AD. On the other hand, CysC binds Aβ and inhibits formation of Aβ fibrils and oligomers both in vitro and in mouse models of amyloid deposition. Thus, deregulation of CysC could be considered a risk factor in the pathogenesis of AD. In the present chapter, we review the role of this inhibitor of proteases in the development, function and generation of neurodegenerative process and weigh the evidence to consider the CysC determination as a useful diagnostic tool for brain disease. 


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Role of Cystatin C in the Neurodegenerative Process and its Possible Use as a Nervous System Biomarker pp. 239-254