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Paediatric Outcomes of Artificial Reproductive Technologies: Lessons from Research pp. 189-204 $100.00
Authors:  (John R. Apps, Alastair G. Sutcliffe, Institute of Child Health, UCL, General Paediatric & Adolescent Unit, London, United Kindgom)
Abstract:
Over 3,500,000 people have been born using Assisted Reproductive Technologies (ART). This chapter reviews the existing research into the health of this population, highlights uncertainties and attempts to draw lessons for future practice and research. The introduction of artificial methods to augment an already complex biological phenomenon increases the potential for adverse outcomes. Much of the adverse outcome relates to morbidity of higher order pregnancies. Early studies were methodologically limited, however as larger, better designed studies and meta-analyses are published it has become clear that ART children have higher rates of preterm birth, low birth weight and slightly higher rates of congenital anomalies. As existing cohorts get older, evidence regarding longer term biological and sociological outcomes is increasing. Whilst generally reassuring, showing little or no difference in growth, physical health, neurological, neuro-developmental, and psychosocial wellbeing, further
research and longer follow up into both adolescent and adult life is required for these and other outcomes. As newer techniques are developed and become more widespread it will be important to establish prospective surveillance to identify and reduce adverse outcome risk. 


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Paediatric Outcomes of Artificial Reproductive Technologies: Lessons from Research pp. 189-204